Destruxin A
Based on 1 publication(s) in Google Scholar
Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.42%
- CAS 番号: 6686-70-0
- 分子式: C29H47N5O7
- 分子量:577.71
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Destruxin A
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hep 3B2 | IC50 |
0.1 μg/mL
Compound: 2
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Antiviral activity against Hepatitis B virus infected in human Hep3B cells assessed as surface antigen production
Antiviral activity against Hepatitis B virus infected in human Hep3B cells assessed as surface antigen production
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[PMID: 7623030] |
Destruxin A (16 μg/mL; 48 h) exhibits antiproliferative activity against leukemia cell line P388[2].
Destruxin A (0.03-0.33 μg/mL; 48 h) promotes the growth of leukemia cell line P388[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 6686-70-0
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性状 Solid
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分子量 577.71
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分子式 C29H47N5O7
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Color White to off-white
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SMILES
O=C1[C@]2(N(C([C@@]([H])(CC=C)OC(CCNC([C@@H](N(C([C@@]([H])(N(C([C@@]([H])(N1)[C@H](CC)C)=O)C)C(C)C)=O)C)C)=O)=O)=O)CCC2)[H]
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Structure Classification
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Initial Source
Metarhizium anisopliae
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Proc Natl Acad Sci U S A
A Toll pathway effector protects Drosophila specifically from distinct toxins secreted by a fungus or a bacterium. [Abstract]2023 Mar 21;120(12):e2205140120. PMID: 36917667
溶剤 & 溶解度
DMSO : 10 mg/mL (17.31 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gong L, et al. Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One. 2014 May 6;9(5):e96170. [Content Brief]
[2]. Odier F, et al. In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E. Biol Cell. 1992;74(3):267-71. [Content Brief]
[3]. Pal S, et al. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J Biol Chem. 2007 Mar 23;282(12):8969-77. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7310 mL | 8.6549 mL | 17.3097 mL | 43.2743 mL |
| 5 mM | 0.3462 mL | 1.7310 mL | 3.4619 mL | 8.6549 mL | |
| 10 mM | 0.1731 mL | 0.8655 mL | 1.7310 mL | 4.3274 mL | |
| 15 mM | 0.1154 mL | 0.5770 mL | 1.1540 mL | 2.8850 mL |
Destruxin A 関連分類
HY-N6689 関連分類
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