Dichamanetin
Dichamanetin, a C-benzylated flavanone that can be isolated from Piper sarmentosum, is a potent antibacterial and anticancer agent. Dichamanetin displays antibacterial activity against a panel of Gram-positive strains, including resistant S. aureus strains with MIC values in the range of 1-7.5 μg/mL. Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components via mitochondrial-mediated apoptosis. Dichamanetin can be used for colon, prostate, breast cancer and infection research.
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- CAS 番号: 58779-09-2
- 分子式: C29H24O6
- 分子量:468.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | GI |
75 %
Compound: 15
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Cytotoxicity against HEK293 cells assessed as growth inhibition at 40 uM relative to control
Cytotoxicity against HEK293 cells assessed as growth inhibition at 40 uM relative to control
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[PMID: 32067457] |
| HL-60 | ED50 |
>20 μM
Compound: 7
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Inhibition of chymotrypsin-like activity of purified human 20S proteasome in HL60 cells using N-succinyl-Leu-Leu-Val-Tyr-AMC as substrate pre-incubated for 10 mins by fluorimetric assay
Inhibition of chymotrypsin-like activity of purified human 20S proteasome in HL60 cells using N-succinyl-Leu-Leu-Val-Tyr-AMC as substrate pre-incubated for 10 mins by fluorimetric assay
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[PMID: 21973101] |
| HT-29 | ED50 |
>20 μM
Compound: 7
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Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
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[PMID: 21973101] |
| HT-29 | ED50 |
3.6 μM
Compound: 7
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Induction of apoptosis in human HT-29 cells assessed reduction of mitochondrial membrane potential after 2 hrs by using JC1 staining by fluorescence cell-based assay
Induction of apoptosis in human HT-29 cells assessed reduction of mitochondrial membrane potential after 2 hrs by using JC1 staining by fluorescence cell-based assay
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[PMID: 21973101] |
化学情報
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CAS 番号 58779-09-2
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分子量 468.50
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分子式 C29H24O6
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SMILES
OC(C(CC1=C(C=CC=C1)O)=C2O)=C(C(C[C@@H](C3=CC=CC=C3)O4)=O)C4=C2CC5=C(C=CC=C5)O
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Yong Y, et al. Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components through mitochondrial-mediated apoptosis. Anticancer Res. 2013 Dec;33(12):5349-55. [Content Brief]
[2]. Pereira F, et al. Cleistochlamys kirkii chemical constituents: Antibacterial activity and synergistic effects against resistant Staphylococcus aureus strains. J Ethnopharmacol. 2016 Feb 3;178:180-7. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dichamanetin 関連分類
HY-N12686 関連分類
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