58779-09-2
Chemical Structure
Dichamanetin
- CAS No.: 58779-09-2
- Formula:C29H24O6
- Molecular Weight:468.50
InChIKey: WBZSDBHJYZORRP-VWLOTQADSA-N
SMILES: OC(C(CC1=C(C=CC=C1)O)=C2O)=C(C(C[C@@H](C3=CC=CC=C3)O4)=O)C4=C2CC5=C(C=CC=C5)O
Biological Activity: Dichamanetin, a C-benzylated flavanone that can be isolated from Piper sarmentosum, is a potent antibacterial and anticancer agent. Dichamanetin displays antibacterial activity against a panel of Gram-positive strains, including resistant S. aureus strains with MIC values in the range of 1-7.5 μg/mL. Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components via mitochondrial-mediated apoptosis. Dichamanetin can be used for colon, prostate, breast cancer and infection research[1][2].
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Dichamanetin | Dichamanetin, a C-benzylated flavanone that can be isolated from Piper sarmentosum, is a potent antibacterial and anticancer agent. Dichamanetin displays antibacterial activity against a panel of Gram-positive strains, including resistant S. aureus strains with MIC values in the range of 1-7.5 μg/mL. Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components via mitochondrial-mediated apoptosis. Dichamanetin can be used for colon, prostate, breast cancer and infection research. | |||||||||||||||||||||
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References
- [1]. Yong Y, et al. Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components through mitochondrial-mediated apoptosis. Anticancer Res. 2013 Dec;33(12):5349-55. [Content Brief]
- [2]. Pereira F, et al. Cleistochlamys kirkii chemical constituents: Antibacterial activity and synergistic effects against resistant Staphylococcus aureus strains. J Ethnopharmacol. 2016 Feb 3;178:180-7. [Content Brief]
