Diphenyl Phosphate
Based on 1 Customer Validation
Diphenyl Phosphate inhibits growth and energy metabolism in zebrafish and mice in a sex-specific manner. Diphenyl Phosphate can inhibit the activity of SDH (respiratory complex II), reduce the expression of CPT1 and disrupts the integrity of the mitochondrial membrane. Diphenyl Phosphate may be used in research on metabolic diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 838-85-7
- 分子式: C12H11O4P
- 分子量:250.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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生物活性
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CPT-1 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Primigravida ICR mice (days 1-10 post-birth)[2]
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Dosage:2 or 200 mg
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Administration:Subcutaneous injection (s.c.), once daily for 10 days
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Result:Exposure increased the body weight of male offspring and led to an increase in lipid, taurine, unsaturated fatty acids, polyunsaturated fatty acids, and phosphatidylcholine in male metabolic profiles at a low dose, while having no significant effect on female mice.
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Animal Model:Zebrafish[1]
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Dosage:0.8, 3.9, 35.6 μg/L
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Administration:Exposure (in the aquatic environment of zebrafish), 120 days
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Result:Caused significant decreases in body mass and body length of male zebrafish (at the dose of 35.6 μg/L), whereas no significantly effects were observed for female zebrafish.
化学情報
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CAS 番号 838-85-7
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性状 Solid
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分子量 250.19
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分子式 C12H11O4P
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Color White to off-white
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SMILES
O=P(OC1=CC=CC=C1)(OC2=CC=CC=C2)O
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別名
DPhP; りん酸ジフェニル
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (399.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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参考文献
[1]. Chen Q, et al. Life Cycle Exposure to Environmentally Relevant Concentrations of Diphenyl Phosphate (DPhP) Inhibits Growth and Energy Metabolism of Zebrafish in a Sex-Specific Manner. Environ Sci Technol. 2021 Oct 5;55(19):13122-13131. [Content Brief]
[2]. Wang D, et al. Neonatal triphenyl phosphate and its metabolite diphenyl phosphate exposure induce sex- and dose-dependent metabolic disruptions in adult mice. Environ Pollut. 2018 Jun;237:10-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9970 mL | 19.9848 mL | 39.9696 mL | 99.9241 mL |
| 5 mM | 0.7994 mL | 3.9970 mL | 7.9939 mL | 19.9848 mL | |
| 10 mM | 0.3997 mL | 1.9985 mL | 3.9970 mL | 9.9924 mL | |
| 15 mM | 0.2665 mL | 1.3323 mL | 2.6646 mL | 6.6616 mL | |
| 20 mM | 0.1998 mL | 0.9992 mL | 1.9985 mL | 4.9962 mL | |
| 25 mM | 0.1599 mL | 0.7994 mL | 1.5988 mL | 3.9970 mL | |
| 30 mM | 0.1332 mL | 0.6662 mL | 1.3323 mL | 3.3308 mL | |
| 40 mM | 0.0999 mL | 0.4996 mL | 0.9992 mL | 2.4981 mL | |
| 50 mM | 0.0799 mL | 0.3997 mL | 0.7994 mL | 1.9985 mL | |
| 60 mM | 0.0666 mL | 0.3331 mL | 0.6662 mL | 1.6654 mL | |
| 80 mM | 0.0500 mL | 0.2498 mL | 0.4996 mL | 1.2491 mL | |
| 100 mM | 0.0400 mL | 0.1998 mL | 0.3997 mL | 0.9992 mL |
Diphenyl Phosphate 関連分類
HY-W008151 関連分類
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