Donanemab (Mouse IgG2a)
Based on 1 publication(s) in Google Scholar
Donanemab (Mouse IgG2a) (mE8-IgG2a) is a mouse-derived IgG2 monoclonal antibody used in the research of Alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- 分子量:146.3 kDa
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
MedChemExpress(MCE)の使用を引用している文献 Donanemab (Mouse IgG2a)
More
生物活性
Mouse IgG2a kappa
Human
Donanemab (Mouse IgG2a) (4-12.5 mg/kg; s.c.; weekly for 6 months) shows a significant dose-dependent decrease in Aβ42 in hippocampus and cortex in sixteen-month-old PDAPP mice[1].
Donanemab (Mouse IgG2a) (i.p.) reduces Aβ plaque in a dose-dependent manner in PDAPP mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Amyloid Beta/Aβ
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
-
Flow Cytometry analysis of HUVEC cells labelling pGlu3Aβ (red) with Donanemab (anti-pGlu3Aβ) (HY-P991045). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG H&L (HY-P8005) at a dilution of 1/1000 was used as the secondary antibody. Blue-Mouse IgG2a kappa (HY-P99978). Black-Unlabelled control, cells without incubation with primary antibody.
化学情報
-
性状 Liquid
-
分子量 146.3 kDa
-
Color Colorless to light yellow
-
SMILES
[Donanemab (Mouse IgG2a)]
-
別名
mE8‑IgG2a
-
輸送条件
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
純度とドキュメンテーション
-
データシート (257 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Demattos RB, et al. A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice. Neuron. 2012 Dec 6;76(5):908-20. [Content Brief]
[2]. Cummings J, et al. Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer's Disease. BioDrugs. 2024 Jan;38(1):5-22. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)