Donanemab (Mouse IgG2a)
Based on 1 publication(s) in Google Scholar
Donanemab (Mouse IgG2a) (mE8-IgG2a) is a mouse-derived IgG2 monoclonal antibody used in the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- Purity: 99.9%
- Molecular Weight:146.3 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Donanemab (Mouse IgG2a)
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Biological Activity
Mouse IgG2a kappa
Human
Donanemab (Mouse IgG2a) (4-12.5 mg/kg; s.c.; weekly for 6 months) shows a significant dose-dependent decrease in Aβ42 in hippocampus and cortex in sixteen-month-old PDAPP mice[1].
Donanemab (Mouse IgG2a) (i.p.) reduces Aβ plaque in a dose-dependent manner in PDAPP mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Amyloid Beta/Aβ
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
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Flow Cytometry analysis of HUVEC cells labelling pGlu3Aβ (red) with Donanemab (anti-pGlu3Aβ) (HY-P991045). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG H&L (HY-P8005) at a dilution of 1/1000 was used as the secondary antibody. Blue-Mouse IgG2a kappa (HY-P99978). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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Appearance Liquid
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Molecular Weight 146.3 kDa
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Color Colorless to light yellow
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SMILES
[Donanemab (Mouse IgG2a)]
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Synonyms
mE8‑IgG2a
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Demattos RB, et al. A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice. Neuron. 2012 Dec 6;76(5):908-20. [Content Brief]
[2]. Cummings J, et al. Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer's Disease. BioDrugs. 2024 Jan;38(1):5-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Donanemab (Mouse IgG2a) Related Classifications
HY-P991045 Related Classifications
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