Donanemab (Mouse IgG2a)
Based on 1 publication(s) in Google Scholar
Donanemab (Mouse IgG2a) (mE8-IgG2a) is a mouse-derived IgG2 monoclonal antibody used in the research of Alzheimer's disease.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.9%
- 분자량:146.3 kDa
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Donanemab (Mouse IgG2a)
More
Biological Activity
Mouse IgG2a kappa
Human
Donanemab (Mouse IgG2a) (4-12.5 mg/kg; s.c.; weekly for 6 months) shows a significant dose-dependent decrease in Aβ42 in hippocampus and cortex in sixteen-month-old PDAPP mice[1].
Donanemab (Mouse IgG2a) (i.p.) reduces Aβ plaque in a dose-dependent manner in PDAPP mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Amyloid Beta/Aβ
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
-
Flow Cytometry analysis of HUVEC cells labelling pGlu3Aβ (red) with Donanemab (anti-pGlu3Aβ) (HY-P991045). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG H&L (HY-P8005) at a dilution of 1/1000 was used as the secondary antibody. Blue-Mouse IgG2a kappa (HY-P99978). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
-
Appearance Liquid
-
분자량 146.3 kDa
-
Color Colorless to light yellow
-
SMILES
[Donanemab (Mouse IgG2a)]
-
Synonyms
mE8‑IgG2a
-
선적
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
순도&문서
-
Data Sheet (257 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
[1]. Demattos RB, et al. A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice. Neuron. 2012 Dec 6;76(5):908-20. [Content Brief]
[2]. Cummings J, et al. Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer's Disease. BioDrugs. 2024 Jan;38(1):5-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)