CEACAM3 - CEA cell adhesion molecule 3 Gene

Also Known as CEA; CGM1; W264; W282; CD66D

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 1084

About CEACAM3

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,796,587-41,811,554 (from NCBI)

This gene has 8 transcripts (splice variants), 559 orthologues, 24 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 11.7), appendix (RPKM 5.0) and 3 other tissues.

Summary

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several Bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several Bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]

CEACAM3 Products (2)

mRNA Protein Name
NM_001277163.3 NP_001264092.1 carcinoembryonic antigen-related cell adhesion molecule 3 isoform 2 precursor
NM_001815.5 NP_001806.2 carcinoembryonic antigen-related cell adhesion molecule 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
27442026 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEACAM3 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (40 - 140)

  • 0
  • 100
  • 200
  • 252 a.a.
Protein Preferred Names Protein Names

carcinoembryonic antigen-related cell adhesion molecule 3

  • CD66d antigen

CEACAM3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CEACAM3 P40198 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
CEACAM3 P40198 CNIH3 Homo sapiens Q8TBE1
Validated Y2H
32296183
Cross
CEACAM3 P40198 opaH Neisseria gonorrhoeae Q04884
FPS
27442026
Cross
CEACAM3 P40198 opaD Neisseria gonorrhoeae Q04883
FPS
27442026
Intra
CEACAM3 P40198 NINJ1 Homo sapiens Q92982
Validated Y2H
32296183
Intra
CEACAM3 P40198 PMP22 Homo sapiens Q01453
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CEACAM3 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P72130 CEACAM3 Protein, Human (His-SUMO) P40198 (K35-G155) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72694 CEACAM3 Protein, Human (HEK293, His) P40198 (K35-G155) ≥ 95%, as determined by reducing SDS-PAGE.

CEACAM3 抗体

製品番号 製品名 アプリケーション 反応性
HY-P84294 CEACAM3 Antibody (YA3991) WB, FC, ELISA Human, Rat
HY-P84294A CEACAM3 Antibody (YA3991)(PBS only) WB, FC, ELISA Human, Rat

関連疾患

Diseases Alias
Mucinous Cystadenocarcinoma

  • Cystadenocarcinoma, Mucinous

  • Pseudomucinous Cystadenocarcinoma

  • Cystadenocarcinoma Mucinous
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Chronic Gonococcal Salpingitis

  • Gonococcal Salpingitis
Acute Salpingitis
Thymic Carcinoma

  • Malignant Thymoma

  • Thymoma, Malignant
Cystadenocarcinoma
Pulmonary Alveolar Proteinosis
Bile Duct Adenoma

  • Cholangioadenoma

  • Adenoma Bile Duct

  • Adenoma, Bile Duct
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Chordoma

  • CHDM

  • Notochordoma

  • Notochordal Sarcoma

  • Chordoma, Susceptibility To

  • Chordocarcinoma

  • Chordoepithelioma
Cystadenoma

  • Cystoma

  • Craniopharyngioma
Carcinosarcoma

  • Mixed Tumor, Mullerian

  • Malignant Mixed Mesodermal Tumor

  • Malignant Mixed Mullerian Tumor

  • Mmmt

  • Mixed Tumor, Mesodermal

  • Mesodermal Mixed Tumor

  • Mixed Mesodermal Tumor

  • Mullerian Mixed Tumor

  • Mixed Mullerian Tumor

  • Malignant Mixed Müllerian Tumor

  • Mixed Müllerian Tumor

  • Mixed Tumor Mullerian

  • Mixed Tumor, Not Otherwise Specified
Mesothelioma, Malignant

  • Malignant Mesothelioma

  • Pleural Mesothelioma

  • MESOM

  • Mesothelioma, Somatic

  • Advanced Malignant Mesothelioma

  • Asbestos-Related Malignant Mesothelioma

  • Diffuse Malignant Mesothelioma

  • Malignant Tumor Of Mesothelium

  • Malignant Mesothelioma, Susceptibility To

  • Mesothelioma Diffuse Malignant

  • Mesothelioma

  • Malignant Pleural Mesothelioma
Large Cell Carcinoma

  • Carcinoma, Large Cell

  • Carcinoma Large Cell
Myxedema
Chronic Salpingitis
Paget Disease, Extramammary

  • Extramammary Paget Disease

  • Cutaneous Paget'S Disease

  • Extramammary Paget'S Disease

  • Paget Disease Extramammary

  • Cutaneous Paget Disease

  • Paget'S Disease Of Skin

  • Empd

  • Extramammary Pagets Disease
Cholangiocarcinoma

  • Cholangiocarcinoma, Susceptibility To

  • Extrahepatic Cholangiocarcinoma

  • Intrahepatic Cholangiocarcinoma

  • Chlc

  • Chlc, Susceptibility To

  • Cc

  • Cholangiocarcinoma Of Biliary Tract

  • Cholangiocellular Carcinoma

  • Distal Cholangiocarcinoma

  • Perihilar Cholangiocarcinoma

  • Bile Duct Cancer

  • Cca

  • Adult Primary Cholangiocellular Carcinoma

  • Bile Duct Carcinoma
Fallopian Tube Disease

  • Fallopian Tube Diseases
Ophthalmia Neonatorum

  • Gonococcal Conjunctivitis

  • Gonococcal Ophthalmia Neonatorum

  • Neonatal Conjunctivitis
Polycystic Liver Disease 1 With Or Without Kidney Cysts

  • Polycystic Liver Disease 1

  • PCLD1

  • Cyst

  • Liver Disease, Polycystic, Type 1

  • Polycystic Liver Disease
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Sertoli-Leydig Cell Tumor

  • Sertoli-Leydig Cell Tumors

  • Androblastoma Of Ovary

  • Arrhenoblastoma

  • Arrhenoblastoma Of Ovary

  • Sertoli-Leydig Cell Tumor Of The Ovary

  • Sertoli-Leydig Cell Tumor Of Intermediate Differentiation

  • Sertoli-Leydig Cell Tumor Of Ovary
Gallbladder Cancer

  • Gallbladder Carcinoma

  • Gallbladder Neoplasm

  • Malignant Neoplasm Of Gallbladder

  • Malignant Tumour Of Gallbladder

  • Gallbladder Ca

  • Localized Malignant Gallbladder Neoplasm

  • Malignant Tumor Of The Gallbladder

  • Tumor Of The Gallbladder

  • Cancer Of The Gallbladder

  • Carcinoma Gallbladder

  • Carcinoma Of Gallbladder

  • Gallbladder Neoplasms

  • Malignant Neoplasm Of Gallbladder Localized

  • Cancer Of Gallbladder

  • Primary Malignant Neoplasm Of Gallbladder
Adenoid Cystic Carcinoma

  • Adenocystic Carcinoma

  • Cribriform Carcinoma

  • Cylindroma

  • Carcinoma Adenoid Cystic

  • Carcinoma, Adenoid Cystic

  • Adenoid Cystic Carcinoma Of Salivary Gland

  • Eccrine Dermal Cylindroma

  • Carcinoma, Cribriform
Bacterial Conjunctivitis

  • Purulent Conjunctivitis

  • Conjunctivitis, Bacterial
Cheilitis
Thyroid Carcinoma, Familial Medullary

  • Medullary Thyroid Carcinoma

  • Familial Medullary Thyroid Carcinoma

  • MTC

  • Medullary Thyroid Cancer

  • Fmtc

  • Mtc1

  • Thyroid Cancer, Medullary

  • Thyroid Carcinoma, Medullary

  • Familial Mtc

  • Thyroid Carcinoma Medullary

  • Carcinoma, Thyroid, Medullary, Familial

  • Medullary Carcinoma Of Thyroid

  • Medullary Carcinoma With Amyloid Stroma, Unspecified Site

  • Medullary Carcinoma With Amyloid Stroma Of Thyroid
Gastrointestinal Carcinoma

  • Gastrointestinal Neoplasms
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Rectum Cancer

  • Malignant Neoplasm Of Rectum

  • Rectal Cancer

  • Cancer Of Rectum

  • Carcinoma Of Rectum

  • Carcinoma Of The Rectum

  • Malignant Rectal Tumor

  • Malignant Rectum Tumor

  • Malignant Tumor Of Rectum

  • Rectal Carcinoma

  • Rectal Cancers

  • Cancer, Rectal
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Glycogen Storage Disease

  • Glycogenosis

  • Glycogenoses

  • Gsd

  • Storage Disease, Glycogen

  • Gsd - [Glycogen Storage Disease]

  • Glycogen Thesaurismosis

  • Diffuse Glycogenosis

  • Generalised Glycogen Storage Disease

  • Generalised Glycogenosis

  • Generalised Glycogen Storage Disease Of Infants

  • Glycogen Synthase Deficiency
Basal Cell Carcinoma

  • Basal Cell Cancer

  • Basal Cell Neoplasm

  • Basal Cell Carcinoma Of Skin

  • Malignant Basal Cell Tumor

  • Basal Cell Tumor

  • Epithelioma Basal Cell

  • Malignant Basal Cell Neoplasm

  • Rodent Ulcer

  • Carcinoma Basal Cell

  • Neoplasms, Basal Cell

  • Basal Cell Carcinomas

  • Experimental Organism Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Basalioma

  • Basal Cell Epithelioma Of Skin

  • Bcc - [Basal Cell Carcinoma] Of Skin

  • Rodent Ulcer Of Skin

  • Rodent Ulcer Of Unspecified Site

  • Basal Cell Epithelioma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS02438 CEACAM21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02439 CEACAM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P990854 Anti-CEACAM1/3/5/6/8 Antibody (6G5j) Inhibitor / Unkown