CEACAM3 Antibody (YA3991)(PBS only)
(Synonyms: CEA; CGM1; W264; W282; CD66D)CEACAM3 Antibody (YA3991) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CEACAM3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, FC, ELISA
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
CEACAM3 Antibody (YA3991) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CEACAM3.
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Host Mouse
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 40-50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 27 kDa
Purified recombinant fragment of human CEACAM3 (AA: 35-155) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CEACAM3 is a Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis
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Subcellular Localization
Membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney -
Isoforms & Post-Translational Modification
P40198 has 3 isomers: P40198-1: 27091 Da (predicted); P40198-2: 19403 Da (predicted); P40198-3: 22754 Da (predicted).
Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected -
Subunit
Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation
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SwissProt ID
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Synonyms
CEA; CGM1; W264; W282; CD66D
Documentation
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