DAB1 - DAB adaptor protein 1 Gene

Also Known as SCA37

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 1600

About DAB1

Cytogenetic location: 1p32.2-p32.1 Genomic coordinates (GRCh38): 1:56,994,778-58,546,726 (from NCBI)

This gene has 11 transcripts (splice variants), 294 orthologues, 11 paralogues and is associated with 2 phenotypes. Biased expression in small intestine (RPKM 6.3), duodenum (RPKM 4.1) and 7 other tissues.

Summary

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]

DAB1 Products (11)

mRNA	Protein	Name
NM_001353980.2	NP_001340909.1	disabled homolog 1 isoform 2
NM_001353983.2	NP_001340912.1	disabled homolog 1 isoform 1
NM_001353985.2	NP_001340914.1	disabled homolog 1 isoform 1
NM_001353986.2	NP_001340915.1	disabled homolog 1 isoform 3
NM_001365792.1	NP_001352721.1	disabled homolog 1 isoform 1
NM_001365793.1	NP_001352722.1	disabled homolog 1 isoform 1
NM_001365794.2	NP_001352723.1	disabled homolog 1 isoform 2
NM_001365795.2	NP_001352724.1	disabled homolog 1 isoform 2
NM_001379461.1	NP_001366390.1	disabled homolog 1 isoform 3
NM_001379462.1	NP_001366391.1	disabled homolog 1 isoform 1
NM_021080.5	NP_066566.3	disabled homolog 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAB1 Protein Structure

PID

0
100
200
300
400
500
588 a.a.

Protein Preferred Names	Protein Names
disabled homolog 1	DAB1, reelin adaptor protein

DAB1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DAB1	O75553	ROR2	Homo sapiens	A1L4F5	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	SIRPB1	Homo sapiens	O00241-2	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	SIRPB1	Homo sapiens	O00241-2	Y2H Array	25416956
Intra	DAB1	O75553	TMTC3	Homo sapiens	Q6ZXV5	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	TMTC3	Homo sapiens	Q6ZXV5	Y2H Array	25416956
Intra	DAB1	O75553	ZBTB32	Homo sapiens	A0A0C4DGF1	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	ZBTB32	Homo sapiens	A0A0C4DGF1	Y2H Array	25416956
Intra	DAB1	O75553	ZBTB32	Homo sapiens	A0A0C4DGF1	Validated Y2H	25416956
Intra	DAB1	O75553	VENTX	Homo sapiens	O95231	Y2H Array	31515488
Intra	DAB1	O75553	MBNL1	Homo sapiens	Q86VM6	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	MBNL1	Homo sapiens	Q86VM6	Y2H Array	25416956
Intra	DAB1	O75553	LGALS9B	Homo sapiens	Q3B8N2	Validated Y2H	25416956
Intra	DAB1	O75553	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	25416956
Intra	DAB1	O75553	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	TOLLIP	Homo sapiens	Q6FIE9	Y2H Array	25416956
Intra	DAB1	O75553	TCEA2	Homo sapiens	Q86VL0	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	25416956
Intra	DAB1	O75553	CIART	Homo sapiens	Q8N365	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	CIART	Homo sapiens	Q8N365	Validated Y2H	25416956
Intra	DAB1	O75553	q9h9i0_human	Homo sapiens	Q9H9I0	Y2H Array	25416956
Intra	DAB1	O75553	q9h9i0_human	Homo sapiens	Q9H9I0	Validated Y2H	25416956
Intra	DAB1	O75553	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	25416956
Intra	DAB1	O75553	POGZ	Homo sapiens	Q7Z3K3	Y2H Array	25416956
Intra	DAB1	O75553	NAF1	Homo sapiens	Q96HR8	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	NAF1	Homo sapiens	Q96HR8	Validated Y2H	25416956
Intra	DAB1	O75553	MBNL1	Homo sapiens	Q9NR56	Y2H Array	25416956
Intra	DAB1	O75553	MBNL1	Homo sapiens	Q9NR56	Y2H Array	29892012
Intra	DAB1	O75553	MBNL1	Homo sapiens	Q9NR56	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	SMAP2	Homo sapiens	Q8WU79	Validated Y2H	25416956
Intra	DAB1	O75553	RHOXF2	Homo sapiens	Q9BQY4	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	RHOXF2	Homo sapiens	Q9BQY4	Y2H Array	25416956
Intra	DAB1	O75553	SNRPB	Homo sapiens	P14678-2	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	SNRPB	Homo sapiens	P14678-2	Y2H Array	25416956
Intra	DAB1	O75553	HYAL3	Homo sapiens	O43820	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	PPIG	Homo sapiens	Q13427	Y2H Array	25416956
Intra	DAB1	O75553	PPIG	Homo sapiens	Q13427	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	PPIG	Homo sapiens	Q13427	Validated Y2H	25416956
Intra	DAB1	O75553	HNRNPLL	Homo sapiens	Q8WVV9	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	MBNL3	Homo sapiens	Q9NUK0	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	MBNL3	Homo sapiens	Q9NUK0	Y2H Array	25416956
Intra	DAB1	O75553	TCEA2	Homo sapiens	Q15560	Validated Y2H	25416956
Intra	DAB1	O75553	TCEA2	Homo sapiens	Q15560	Y2H Array	25416956
Intra	DAB1	O75553	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	PIN1	Homo sapiens	Q13526	Y2H Array	25416956
Intra	DAB1	O75553	PIN1	Homo sapiens	Q13526	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	25416956
Intra	DAB1	O75553	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	DAB1	O75553	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	DAB1	O75553	LNX1	Homo sapiens	Q8TBB1	Y2H Array	31515488
Intra	DAB1	O75553	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	STRBP	Homo sapiens	Q96SI9	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	STRBP	Homo sapiens	Q96SI9	Y2H Array	25416956
Intra	DAB1	O75553	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	DAB1	O75553	ZC3H10	Homo sapiens	Q96K80	Validated Y2H	25416956
Intra	DAB1	O75553	RAMAC	Homo sapiens	Q9BTL3	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	RBFOX2	Homo sapiens	O43251	Y2H Array	25416956
Intra	DAB1	O75553	TOLLIP	Homo sapiens	Q9H0E2	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	DAB1	O75553	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956
Intra	DAB1	O75553	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	ZNF488	Homo sapiens	Q96MN9	Y2H Prey Pooling	25416956
Intra	DAB1	O75553	ZNF488	Homo sapiens	Q96MN9	Validated Y2H	25416956
Intra	DAB1	O75553	ZNF488	Homo sapiens	Q96MN9	Y2H Array	25416956
Intra	DAB1	O75553	TCEANC	Homo sapiens	Q8N8B7	Validated Y2H	25416956
Intra	DAB1	O75553	TCEANC	Homo sapiens	Q8N8B7	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

DAB1 抗体

製品番号	製品名	アプリケーション	反応性
HY-P810865	DAB1 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P811180	DAB1/ Disabled homolog 1 Antibody	WB, ICC/IF	Human, Mouse, Rat

関連疾患

Diseases	Alias
Spinocerebellar Ataxia 37	Spinocerebellar Ataxia Type 37 SCA37 Spinocerebellar Ataxia With Altered Vertical Eye Movements
Spastic Ataxia	Spax Ataxia, Spastic
Epilepsy, Familial Adult Myoclonic, 6	FAME6 Benign Adult Familial Myoclonic Epilepsy 6 Bafme6 Fcmte6 Cortical Myoclonic Tremor With Epilepsy, Familial, 6 Familial Adult Myoclonic Epilepsy 6 Familial Cortical Myoclonic Tremor And Epilepsy 6 Epilepsy, Myoclonic, Familial Adult, Type 6
Cerebellar Ataxia Type 43	Sca43
Spinocerebellar Ataxia, X-Linked 1	X-Linked Progressive Cerebellar Ataxia SCAX1 Opcax X-Linked Spinocerebellar Ataxia 1 Olivopontocerebellar Atrophy, X-Linked Opca, X-Linked Olivopontocerebellar Atrophy X-Linked Opca X-Linked Ataxia, Spinocerebellar, X-Linked Type 1
Spinocerebellar Ataxia 35	Spinocerebellar Ataxia Type 35 SCA35 Ataxia, Spinocerebellar, Type 35
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Cerebellar Ataxia Type 47	Sca47
Epilepsy, Familial Adult Myoclonic, 7	FAME7 Bafme7 Fcmte7 Benign Adult Familial Myoclonic Epilepsy 7 Cortical Myoclonic Tremor With Epilepsy, Familial, 7 Familial Adult Myoclonic Epilepsy 7 Familial Cortical Myoclonic Tremor And Epilepsy 7 Benign Adult Familial Myoclonic Epilepsy 27 Epilepsy, Myoclonic, Familial Adult, Type 7
Epilepsy, Familial Adult Myoclonic, 1	FAME1 Benign Adult Familial Myoclonic Epilepsy 1 Bafme1 Fcmte1 Cortical Myoclonic Tremor With Epilepsy, Familial, 1 Familial Adult Myoclonic Epilepsy 1 Familial Cortical Myoclonic Tremor And Epilepsy 1 Epilepsy, Myoclonic, Familial Adult, Type 1
Spinocerebellar Ataxia, Autosomal Recessive 4	SCAR4 Scasi Spinocerebellar Ataxia With Saccadic Intrusions Autosomal Recessive Cerebellar Ataxia-Saccadic Intrusion Syndrome Spinocerebellar Ataxia 24 Autosomal Recessive Spinocerebellar Ataxia 4 Sca24 Spinocerebellar Ataxia 24, Formerly Sca24, Formerly Spinocerebellar Ataxia Autosomal Recessive 4 Autosomal Recessive Cerebellar Ataxia-Movement Disorder Syndrome
X-Linked Cerebellar Ataxia
Boucher-Neuhauser Syndrome	Ataxia-Hypogonadism-Choroidal Dystrophy Syndrome BNHS Spinocerebellar Ataxia, Hypogonadotropic Hypogonadism, And Chorioretinal Dystrophy Boucher-Neuhäuser Syndrome Chorioretinal Dystrophy, Spinocerebellar Ataxia, And Hypogonadotropic Hypogonadism Ataxia - Hypogonadism - Choroidal Dystrophy Chorioretinal Dystrophy, Spinocerebellar Ataxia And Hypogonadotropic Hypogonadism Bns Cerebellar Ataxia With Hypogonadism And Choroidal Dystrophy Syndrome Boucher Neuhauser Syndrome
Epilepsy, Familial Adult Myoclonic, 3	FAME3 Fcmte3 Cortical Myoclonic Tremor With Epilepsy, Familial, 3 Familial Adult Myoclonic Epilepsy 3 Familial Cortical Myoclonic Tremor And Epilepsy 3 Epilepsy, Myoclonic, Familial Adult, Type 3
Familial Adult Myoclonic Epilepsy	Benign Adult Familial Myoclonus Epilepsy Bafme Benign Adult Familial Myoclonic Epilepsy Fame Familial Cortical Myoclonic Tremor And Epilepsy Fcmte Adcme Autosomal Dominant Cortical Myoclonus And Epilepsy Fam Epilepsy, Myoclonic, Familial Adult Epilepsy, Myoclonic, Benign Adult Familial, Type 2
Spinocerebellar Ataxia 31	Spinocerebellar Ataxia Type 31 SCA31 Spinocerebellar Ataxia 16q22-Linked Spinocerebellar Ataxia, 16q22-Linked Pure Spinocerebellar Ataxia Japanese Type Sca4 Pure Japanese Type Ataxia, Spinocerebellar, Type 31
Spinocerebellar Ataxia 10	Spinocerebellar Ataxia Type 10 SCA10 Spinocerebellar Ataxia-10 Ataxia, Spinocerebellar, Type 10
Epilepsy, Familial Adult Myoclonic, 2	FAME2 Benign Adult Familial Myoclonic Epilepsy 2 Bafme2 Fcmte2 Adcme Cortical Myoclonic Tremor With Epilepsy, Familial, 2 Cortical Myoclonus And Epilepsy, Autosomal Dominant Familial Adult Myoclonic Epilepsy 2 Epilepsy, Myoclonic, Benign Adult Familial, Type 2 Autosomal Dominant Cortical Myoclonus And Epilepsy Familial Cortical Myoclonic Tremor And Epilepsy 2 Epilepsy, Myoclonic, Familial Adult, Type 2
Spinocerebellar Ataxia 36	Spinocerebellar Ataxia Type 36 SCA36 Asidan Ataxia Costa De Morte Ataxia Asidan Ataxia, Spinocerebellar, Type 36
Adolescence-Adult Electroclinical Syndrome
Epilepsy, Familial Temporal Lobe, 7	Familial Temporal Lobe Epilepsy 7 ETL7 Epilepsy, Temporal Lobe, Familial, Type 7
Cerebellar Ataxia Type 48	Sca48
Spinocerebellar Ataxia 14	Spinocerebellar Ataxia Type 14 SCA14 Ataxia, Spinocerebellar, Type 14
Lissencephaly 3	LIS3 Lissencephaly Due To Tuba1a Mutation Lissencephaly Type 3 Lissencephaly, Type 3
Myotonic Dystrophy 2	Myotonic Dystrophy Type 2 Proximal Myotonic Myopathy Promm Ricker Syndrome DM2 Dystrophia Myotonica 2 Myotonic Myopathy, Proximal Myotonic Disorders Dystrophia Myotonica Type 2 Proximal Myotonic Dystrophy Ricker Disease Myotonic Dystrophy, Type 2 Dystrophy, Myotonic, Type 2
Fuchs' Endothelial Dystrophy	Fuchs Endothelial Corneal Dystrophy Fuchs Endothelial Dystrophy Fuchs Dystrophy Fced Fuchs' Corneal Dystrophy Fuchs' Endothelial Corneal Dystrophy Fuchs Atrophy Fuchs Corneal Dystrophy Endoepithelial Corneal Dystrophy Fecd Late Hereditary Endothelial Dystrophy Corneal Dystrophy, Fuchs Endothelial Dystrophy, Corneal, Fuchs Endothelial Corneal Dystrophy, Fuchs' Endothelial, 1
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Episodic Ataxia	Isaacs Syndrome Neuromyotonia Isaacs' Syndrome Acquired Neuromyotonia Continuous Muscle Fiber Activity Syndrome Quantal Squander Syndrome Isaacs-Mertens Syndrome Ea Syndrome Episodic Ataxia Syndrome Isaac Syndrome Isaac'S-Merten'S Syndrome Isaac-Mertens Syndrome Peripheral Nerve Hyperexcitability Ea Peripheral Nerve Hyperexcitability Syndrome Ataxia, Episodic Isaacs Neuromyotonia Continuous Muscle Fibre Activity
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03510	DAB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03840	DNAAF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09781	OMA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19317	Dab1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25808	Dab1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	DAB1	RGD	RGD:628770
Mus musculus	DAB1	MGD	MGI:108554
Macaca mulatta	DAB1	VGNC	VGNC:71723
Bos taurus	DAB1	VGNC	VGNC:27864
Felis catus	DAB1	VGNC	VGNC:61328
Canis familiaris	DAB1	VGNC	VGNC:39758
Others	DAB1	NCBI