DAB1 Antibody
(Synonyms: Disabled homolog 1, DAB1)DAB1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to DAB1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
DAB1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to DAB1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 64 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 63 kDa
Synthetic peptide corresponding to the center region of human DAB1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DAB1 is a Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Mainly expressed in brain. -
Isoforms & Post-Translational Modification
DAB1 has 6 isoforms, O75553-1: amino acid length is 588, molecular weight is 63775 Da (predicted); O75553-2: amino acid length is 213, molecular weight is 24091 Da (predicted); O75553-3: amino acid length is 469, molecular weight is 49856 Da (predicted); O75553-4: amino acid length is 537, molecular weight is 57720 Da (predicted); O75553-5: amino acid length is 553, molecular weight is 59612 Da (predicted); O75553-6: amino acid length is 555, molecular weight is 59950 Da (predicted).胚胎神经元中，在络丝蛋白(reelin)的诱导下，第 198 位酪氨酸(Tyr-198)和第 220 位酪氨酸(Tyr-220)可被 FYN 磷酸化。第 524 位丝氨酸(Ser-524)也会发生磷酸化，且该过程不依赖于 reelin 信号通路DAB1 存在 6 个异构体，O75553-1：氨基酸个数为 588 个，分子量为 63775 Da (预测)；O75553-2：氨基酸个数为 213 个，分子量为 24091 Da (预测)；O75553-3：氨基酸个数为 469 个，分子量为 49856 Da (预测)；O75553-4：氨基酸个数为 537 个，分子量为 57720 Da (预测)；O75553-5：氨基酸个数为 553 个，分子量为 59612 Da (预测)；O75553-6：氨基酸个数为 555 个，分子量为 59950 Da (预测)。Phosphorylated by FYN on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling
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Subunit
Associates with the SH2 domains of SRC, FYN and ABL (By similarity).
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SwissProt ID
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Synonyms
Disabled homolog 1, DAB1
Documentation
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