Tead2 - TEA domain family member 2 Gene

Also Known as ETF; Etdf; TEF4; TEF-4; ETEF-1; TEAD-2

生物種: Mus musculus

遺伝子タイプ: protein coding

遺伝子ID: 21677

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell death. Acts upstream of or within several processes, including cellular response to retinoic acid; mesenchyme development; and tube morphogenesis. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb bud. Orthologous to human TEAD2 (TEA domain transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tead2 Products (5)

mRNA	Protein	Name
NM_001285498.2	NP_001272427.1	transcriptional enhancer factor TEF-4 isoform a
NM_001285500.2	NP_001272429.1	transcriptional enhancer factor TEF-4 isoform b
NM_001379272.1	NP_001366201.1	transcriptional enhancer factor TEF-4 isoform a
NM_001379273.1	NP_001366202.1	transcriptional enhancer factor TEF-4 isoform a
NM_011565.3	NP_035695.1	transcriptional enhancer factor TEF-4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables DNA binding	IDA IDA: Inferred from direct assay	7629195	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14736747	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16207754	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10934189	MGI

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of or within cellular response to retinoic acid	IDA IDA: Inferred from direct assay	21385842	MGI
acts upstream of or within embryonic heart tube morphogenesis	IGI IGI: Inferred from genetic interaction	18332127	MGI
acts upstream of or within lateral mesoderm development	IGI IGI: Inferred from genetic interaction	18332127	MGI
involved in mesenchyme development	IGI IGI: Inferred from genetic interaction	20596238	MGI
involved in nervous system development	IGI IGI: Inferred from genetic interaction	20596238	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	17868131	MGI
acts upstream of or within notochord development	IGI IGI: Inferred from genetic interaction	18332127	MGI
acts upstream of or within paraxial mesoderm development	IGI IGI: Inferred from genetic interaction	18332127	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9502435	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16207754	MGI
acts upstream of or within regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	21385842	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14736747	MGI
acts upstream of or within vasculogenesis	IGI IGI: Inferred from genetic interaction	18332127	MGI

Cellular Component GO Annotation	Evidence	参考文献	由来
part of transcription regulator complex	IDA IDA: Inferred from direct assay	16207754	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcriptional enhancer factor TEF-4	embryonic TEA domain-containing factor

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-B1221	Flufenamic acid		99.98%	Unkown

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-172113	H122		98.33%	Phase 4

Pre-clinical Phase

Bioactive Molecules (15)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-139330	MGH-CP1	Inducer	99.56%	Unkown
HY-147135	MYF-03-69		98.11%	Unkown
HY-158342	PROTAC TEAD degrader-1	Degrader	99.82%	Unkown
HY-161569	TEAD-IN-11	Inhibitor	99.82%	Unkown
HY-B1221S1	Flufenamic acid-13C6		/	Unkown
HY-186117	KG-FP-003	Degrader	/	Unkown
HY-161568	TEAD-IN-10	Inhibitor	/	Unkown
HY-173139	TEAD-IN-19	Inhibitor	/	Unkown
HY-181534	PROTAC TEAD1/IAP degrader-1	Degrader	/	Unkown
HY-183753	LC-TD-05		/	Unkown
HY-184225	PROTAC TEAD degrader-3	Degrader	/	Unkown
HY-B1221S	Flufenamic acid-d4		/	Unkown
HY-RS14343	TEAD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19240	Tead2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25729	Tead2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Tead2	NCBI	NCBI:8463