Pde3b - phosphodiesterase 3B Gene

Also Known as RcGIPl; CGI PDE

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 29516

Summary

Enables 3',5'-cyclic-AMP phosphodiesterase activity and phosphoprotein binding activity. Involved in negative regulation of cAMP-mediated signaling and negative regulation of Insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in membrane. Orthologous to human PDE3B (phosphodiesterase 3B). [provided by Alliance of Genome Resources, Apr 2022]

Pde3b Products (1)

mRNA Protein Name
NM_017229.2 NP_058925.2 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
9631240 RGD
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
9631240 RGD
enables phosphoprotein binding IDA
IDA: Inferred from direct assay
16225849 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in negative regulation of cAMP/PKA signal transduction IMP
IMP: Inferred from mutant phenotype
9884079 RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
18706893 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

cGMP-inhibited 3',5'-cyclic phosphodiesterase B

  • CGI-PDE B

  • CGIPDE1

  • cyclic GMP-inhibited phosphodiesterase B

  • phosphodiesterase 3B, cGMP-inhibited

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
製品番号 製品名 製品効果
純度 Phase
HY-U00186 K134 Inhibitor 99.76% Phase 2
HY-145924 BAY 2666605 Inhibitor 99.74% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-101312 Cilostamide Inhibitor 99.13% Unkown
HY-136350 BRD9500 Modulator 98.41% Unkown
HY-163285 PDE3B-IN-1 Inhibitor 99.60% Unkown
HY-136350B (S)-BRD9500 Control 99.67% Unkown
HY-112631 OPC 33540 Inhibitor / Unkown
HY-168966 JNJ-54082730 / Unkown
HY-179595 GSK4394835A Inhibitor / Unkown
HY-RS10219 PDE3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18399 Pde3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24880 Pde3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Pde3b NCBI NCBI:5140