JNJ-54082730
JNJ-54082730 (Compound 1) is the orally active inhibitor for phosphodiesterase (PDE) that inhibits PDE2A, PDE3B, and PDE10A2 with IC50s of 0.95 nM, 6.17 μM (pIC50=5.21) and 87.1 nM (pIC50=7.06), respectively. JNJ-54082730 modulates the activity of AMPA receptor, enhance the synaptic plasticity and promotes the learning and memory function in rats models. JNJ-54082730 can cross blood-brain barrier.
For research use only. We do not sell to patients.
- CAS No.: 2097493-39-3
- Formula: C20H22F2N6O
- Molecular Weight:400.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Chemical Information
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CAS No. 2097493-39-3
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Molecular Weight 400.43
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Formula C20H22F2N6O
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SMILES
C[C@H]1[C@@H](CN(CC1)C(C2=CC(C)=NC(C)=C2)=O)C3=CC(C(F)F)=NC4=NC=NN34
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNJ-54082730 Related Classifications
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