2097493-39-3
Chemical Structure
JNJ-54082730
- CAS No.: 2097493-39-3
- Formula:C20H22F2N6O
- Molecular Weight:400.43
InChIKey: OKZITNMVZCTKEZ-IAQYHMDHSA-N
SMILES: C[C@H]1[C@@H](CN(CC1)C(C2=CC(C)=NC(C)=C2)=O)C3=CC(C(F)F)=NC4=NC=NN34
Biological Activity: JNJ-54082730 (Compound 1) is the orally active inhibitor for phosphodiesterase (PDE) that inhibits PDE2A, PDE3B, and PDE10A2 with IC50s of 0.95 nM, 6.17 μM (pIC50=5.21) and 87.1 nM (pIC50=7.06), respectively. JNJ-54082730 modulates the activity of AMPA receptor, enhance the synaptic plasticity and promotes the learning and memory function in rats models. JNJ-54082730 can cross blood-brain barrier[1].
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JNJ-54082730 | JNJ-54082730 (Compound 1) is the orally active inhibitor for phosphodiesterase (PDE) that inhibits PDE2A, PDE3B, and PDE10A2 with IC50s of 0.95 nM, 6.17 μM (pIC50=5.21) and 87.1 nM (pIC50=7.06), respectively. JNJ-54082730 modulates the activity of AMPA receptor, enhance the synaptic plasticity and promotes the learning and memory function in rats models. JNJ-54082730 can cross blood-brain barrier. | |||||||||||||||||||||
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Keywords
