PDE3B - phosphodiesterase 3B Gene

Also Known as HcGIP1; cGIPDE1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5140

About PDE3B

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:14,643,804-14,872,044 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 20 paralogues. Biased expression in fat (RPKM 53.0), lymph node (RPKM 8.6) and 12 other tissues.

Summary

Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of angiogenesis; negative regulation of cell adhesion; and negative regulation of lipid catabolic process. Located in membrane. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]

PDE3B Products (3)

mRNA	Protein	Name
NM_000922.4	NP_000913.2	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2
NM_001363569.2	NP_001350498.1	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 3
NM_001363570.2	NP_001350499.1	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	14592490	GOA
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	EXP EXP: Inferred from Experiment	8562305	GOA
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	14592490	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17255105	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	21393242	GOA
involved in negative regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	17884339	GOA
involved in negative regulation of lipid catabolic process	IMP IMP: Inferred from mutant phenotype	11641262	GOA
involved in regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	21840392	GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	21840392	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of guanyl-nucleotide exchange factor complex	IDA IDA: Inferred from direct assay	17884339	GOA
located in membrane	IDA IDA: Inferred from direct assay	18586889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE3B Protein Structure

PDEase_I

0
200
400
600
800
1000
1112 a.a.

Protein Preferred Names	Protein Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B cGMP-inhibited 3',5'-cyclic phosphodiesterase B	CGI-PDE B

Protein Preferred Names

Protein Names

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

cGMP-inhibited 3',5'-cyclic phosphodiesterase B

CGI-PDE B

PDE3B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDE3B	Q13370	PIK3CG	Homo sapiens	P48736	Anti Bait CoIP	21393242
Intra	PDE3B	Q13370	RAPGEF3	Homo sapiens	O95398	Peptide Array	21393242
Intra	PDE3B	Q13370	RAPGEF3	Homo sapiens	O95398	Imaging	21393242
Intra	PDE3B	Q13370	RAPGEF3	Homo sapiens	O95398	Anti Bait CoIP	21393242
Intra	PDE3B	Q13370	RAPGEF3	Homo sapiens	O95398	Pull Down	21393242
Intra	PDE3B	Q13370	PIK3R6	Homo sapiens	Q5UE93	Anti Bait CoIP	21393242
Intra	PDE3B	Q13370	PIK3R6	Homo sapiens	Q5UE93	Anti Tag CoIP	21393242
Intra	PDE3B	Q13370	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pelizaeus-Merzbacher Disease	PMD HLD1 Pelizaeus-Merzbacher Brain Sclerosis Leukodystrophy, Hypomyelinating, 1 Diffuse Familial Brain Sclerosis Pelizaeus Merzbacher Brain Sclerosis Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type Cockayne-Pelizaeus-Merzbacher Disease Hypomyelinating Leukodystrophy 1 Leukodystrophy, Sudanophilic Pelizaeus Merzbacher Disease Hypomyelinating Leukodystrophy, 1 Sudanophilic Leukodystrophy Pelizaeus-Merzbacher Disease, Connatal Form Connatal Pmd Pelizaeus-Merzbacher Disease Type Ii Severe Pmd Null Syndrome Plp1 Null Syndrome Pelizaeus-Merzbacher Disease, Null Syndrome Brain Sclerosis Diffuse Familial Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type Leukodystrophy Hypomyelinating 1 Diffuse Cerebral Sclerosis Of Schilder
Impotence	Erectile Dysfunction Sexual Impotence Erectile Dysfunction Adverse Event
Brachydactyly
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Diabetes Mellitus	Diabetes
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-U00186	K134	Inhibitor	99.76%	Phase 2
HY-145924	BAY 2666605	Inhibitor	99.74%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101312	Cilostamide	Inhibitor	99.13%	Unkown
HY-136350	BRD9500	Modulator	98.41%	Unkown
HY-163285	PDE3B-IN-1	Inhibitor	99.60%	Unkown
HY-136350B	(S)-BRD9500	Control	99.67%	Unkown
HY-112631	OPC 33540	Inhibitor	/	Unkown
HY-168966	JNJ-54082730		/	Unkown
HY-179595	GSK4394835A	Inhibitor	/	Unkown
HY-RS10219	PDE3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18399	Pde3b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24880	Pde3b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PDE3B	VGNC	VGNC:32675
Felis catus	PDE3B	VGNC	VGNC:68757
Macaca mulatta	PDE3B	VGNC	VGNC:75914
Mus musculus	PDE3B	MGD	MGI:1333863
Canis familiaris	PDE3B	VGNC	VGNC:52287
Rattus norvegicus	PDE3B	RGD	RGD:61943
Others	PDE3B	NCBI