PIK3R6 - phosphoinositide-3-kinase regulatory subunit 6 Gene

Also Known as C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 146850

About PIK3R6

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,802,722-8,867,677 (from NCBI)

This gene has 3 transcripts (splice variants), 228 orthologues and 1 paralogue. Broad expression in spleen (RPKM 2.7), appendix (RPKM 1.8) and 19 other tissues.

Summary

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

PIK3R6 Products (2)

mRNA Protein Name
NM_001010855.4 NP_001010855.1 phosphoinositide 3-kinase regulatory subunit 6 isoform 1
NM_001290211.1 NP_001277140.1 phosphoinositide 3-kinase regulatory subunit 6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21393242 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway EXP
EXP: Inferred from Experiment
10358071 GOA
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
21393242 GOA
involved in regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
11062502 GOA
Cellular Component GO Annotation Evidence References Source
part of phosphatidylinositol 3-kinase complex, class IA EXP
EXP: Inferred from Experiment
10358071 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3R6 Protein Structure

PI3K_1B_p101

PI3K_1B_p101: Phosphoinositide 3-kinase gamma adapter protein p101 subunit (3 - 753)

  • 0
  • 200
  • 400
  • 600
  • 753 a.a.
Protein Preferred Names Protein Names

phosphoinositide 3-kinase regulatory subunit 6

  • PI3Kgamma adapter protein of 87 kDa

PIK3R6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PIK3R6 Q5UE93 PDE3B Homo sapiens Q13370
Peptide Array
21393242
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10541 PIK3R6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PIK3R6 RGD RGD:1560850
Bos taurus PIK3R6 VGNC VGNC:32897
Mus musculus PIK3R6 MGD MGI:2144613
Macaca mulatta PIK3R6 VGNC VGNC:75873
Felis catus PIK3R6 VGNC VGNC:64178
Canis familiaris PIK3R6 VGNC VGNC:44563
Others PIK3R6 NCBI