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Art. -Nr.: HY-190259

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PDE3A/B-IN-2

PDE3A/B-IN-2 is a PDE3A/B inhibitor with IC₅₀ values of 280 nM and 270 nM, respectively. PDE3A/B-IN-2 inhibits tumor cell proliferation and modulates the formation of PDE3A-SLFN12 and PDE3B-SLFN12 complexes. PDE3A/B-IN-2 is also a molecular glue (molecular glue). PDE3A/B-IN-2 can be used for cancer research.

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CAS. Nr.: 2275774-53-1
Formel: C₁₅H₁₃F₃N₄O₂
Molecular Weight:338.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDE3A/B-IN-2 Chemical Structure

CAS. Nr.: 2275774-53-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

PDE3A

280 nM (IC₅₀)

PDE3B

270 nM (IC₅₀)

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen :

In Vitro

PDE3A/B-IN-2 (Example 128) inhibits the enzymatic activity of PDE3A and PDE3B in a cell-free system, with IC₅₀ values of 280 nM and 270 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 2275774-53-1
Molecular Weight 338.28
Formel C₁₅H₁₃F₃N₄O₂
SMILES

CC1=C(C2=C(C(F)(F)F)C=C(C3=NNC(OC3)=O)C=C2)C(C)=NN1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ellermann M, et al. Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Broad Institute Inc, Dana-Farber Cancer Institute Inc. Dihydrooxadiazinones. WO 2019/025562 A1. Published 2019 Feb 07.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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PDE3A/B-IN-2

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

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PDE3A/B-IN-2 Related Classifications

HY-190259 Related Classifications

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