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Art. -Nr.: HY-190258

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PDE3A/B-IN-5

PDE3A/B-IN-5 is a PDE3A and PDE3B inhibitor with IC₅₀ values of 6 nM and 4 nM, respectively. PDE3A/B-IN-5 is also a molecular glue. PDE3A/SLFN12 stabilizer-1 can be used in research related to cervical cancer and melanoma.

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CAS. Nr.: 2275774-47-3
Formel: C₁₅H₁₆F₃N₃O₃
Molecular Weight:343.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDE3A/B-IN-5 Chemical Structure

CAS. Nr.: 2275774-47-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

PDE3A

6 nM (IC₅₀)

PDE3B

4 nM (IC₅₀)

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen :

In Vitro

Anti-cancerOthers

Anti-cancer

PDE3A/SLFN12 stabilizer-1 (Example 120) inhibits the proliferation of Hela and SK-MEL-3 cells, with IC₅₀ values of 0.3 nM and 1 nM, respectively^[1].

Others

PDE3A/SLFN12 stabilizer-1 inhibits the enzymatic activity of PDE3A and PDE3B in cell-free systems, with IC₅₀ values of 6 nM and 4 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2275774-47-3
Molecular Weight 343.30
Formel C₁₅H₁₆F₃N₃O₃
SMILES

C[C@H]1C(C2=CC(C(F)(F)F)=C(N3CCOCC3)C=C2)=NNC(O1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ellermann M, et al. Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Broad Institute Inc, Dana-Farber Cancer Institute Inc. Dihydrooxadiazinones. WO 2019/025562 A1. Published 2019 Feb 07.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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PDE3A/B-IN-5

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PDE3A/B-IN-5 Related Classifications

HY-190258 Related Classifications

Bioz

Keywords

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