IL31 - interleukin 31 Gene

Also Known as IL-31

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 386653

About IL31

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,172,029-122,174,221 (from NCBI)

This gene has 1 transcript (splice variant) and 69 orthologues. Low expression observed in reference dataset.

Summary

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating Other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]

IL31 Products (1)

mRNA Protein Name
NM_001014336.2 NP_001014358.1 interleukin-31 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in extracellular space IDA
IDA: Inferred from direct assay
21182835 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL31 Protein Structure

IL31

IL31: Interleukin 31 (24 - 159)

  • 0
  • 100
  • 164 a.a.
Protein Preferred Names Protein Names

interleukin-31

IL31 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
IL31 Q6EBC2 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL31 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P7217 IL-31 Protein, Human Q6EBC2 (S24-T164) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73209 IL-31 Protein, Human (HEK293, His) Q6EBC2/NP_001014358.1 (S24-T164) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700123AF Animal-Free IL-31 Protein, Human (His) Q6EBC2 (S24-T164) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Dermatitis

  • Eczema

  • Skin Inflammation

  • Inflammatory Dermatosis
Allergic Contact Dermatitis

  • Dermatitis, Allergic Contact

  • Contact Dermatitis, Allergic

  • Dermatitis Allergic Contact

  • Allergic Contact Eczema

  • Acd - [Allergic Contact Dermatitis]

  • Allergic Contact Dermatitis, Unspecified Cause

  • Allergic Dermatitis

  • Allergic Eczema

  • Allergy Dermatitis

  • Allergy Eczema

  • Allergic Contact Eczema Due To Clothing Or Footwear

  • Perfume Allergic Contact Dermatitis

  • Allergic Contact Dermatitis Due To Cosmetics

  • Allergic Contact Eczema Due To Cosmetics Or Fragrances

  • Allergic Contact Eczema Due To Dental Materials

  • Allergic Contact Eczema Due To Food Flavours Or Additives

  • Allergic Contact Eczema Due To Hairdressing Products

  • Allergic Contact Eczema Due To Metals Or Metal Salts

  • Allergic Contact Eczema Due To Proteins

  • Allergic Contact Eczema Due To Plastics Or Resin Systems

  • Allergic Contact Eczema Due To Preservatives Or Biocides

  • Allergic Contact Eczema Due To Rubber Chemicals

  • Rubber Dermatitis

  • Allergic Contact Eczema Due To Systemic Medicaments

  • Allergic Contact Eczema Due To Topical Medicaments

  • Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Contact Dermatitis

  • Contact Dermatitis/Eczema

  • Contact Eczema

  • Dermatitis Venenata

  • Dermatitis, Venenata

  • Dermatitis Contact

  • Dermatitis, Contact
Primary Cutaneous Amyloidosis

  • Plca

  • Primary Localized Cutaneous Amyloidosis

  • Familial Primary Localized Cutaneous Amyloidosis

  • Amyloidosis Ix

  • Lichen Amyloidosis Familial

  • Amyloidosis, Primary Cutaneous

  • Pca

  • Amyloidosis 9

  • Amyloidosis Familial Cutaneous Lichen

  • Fplca

  • Familial Lichen Amyloidosis
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Dermatitis Herpetiformis

  • Duhring'S Disease

  • Duhring-Brocq Disease

  • Dermatosis Herpetiformis

  • Brocq-Duhring Disease

  • Dh

  • Duhring Brocq Disease

  • Dh - [Dermatitis Herpetiformis]
Mastocytosis, Cutaneous

  • Urticaria Pigmentosa

  • Cutaneous Mastocytosis

  • Diffuse Cutaneous Mastocytosis

  • Maculopapular Cutaneous Mastocytosis

  • Mastocytosis, Diffuse Cutaneous

  • MASTC

  • Mastocytosis, Maculopapular Cutaneous

  • Mastocytosis, Systemic, Somatic

  • Mastocytoma

  • Dcm

  • Diffuse Cutaneous Maculopapulous Mastocytosis

  • Up/Mpcm

  • Cm

  • Mastocytosis, Systemic

  • MASTSYS

  • Mast Cell Disease

  • Mast-Cell Disease

  • Mast Cell Leukemia

  • Mastocytosis, Indolent

  • Mastocytosis With Associated Hematologic Disorder

  • Mast Cell Neoplasm

  • Benign Mastocytoma
Neurodermatitis
Mite Infestation

  • Mite Infestations

  • Acariasis

  • Infestation By Mites Nos
Chronic Spontaneous Urticaria

  • Chronic Idiopathic Urticaria
Pemphigoid
Eczema Herpeticum

  • Herpes Simplex Dermatitis

  • Herpes Simplex Eyelid Dermatitis

  • Kaposi Varicelliform Eruption

  • Herpes Simplex Dermatitis Of Eyelid

  • Herpes Simplex Virus Dermatitis

  • Herpes Simplex Virus Eyelid Dermatitis
Urticaria

  • Nettle Rash

  • Hives

  • Wheal

  • Urticaria Nos
Scabies

  • Sarcoptic Itch

  • Infestation By Sarcoptes Scabiei

  • Infestation By Sarcoptes Scabiei Var Hominis

  • Infestation By Sarcoptes Scabiei Var. Hominis
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Psoriasis
Irritant Dermatitis

  • Irritant Contact Dermatitis

  • Primary Irritant Dermatitis

  • Dermatitis, Irritant

  • Contact Dermatitis, Irritant

  • Irritant Contact Eczema

  • Icd - [Irritant Contact Dermatitis]

  • Irritant Contact Dermatitis, Unspecified Cause

  • Non-Allergic Contact Dermatitis

  • Irritant Contact Eczema Due To Wet Work

  • Irritant Contact Dermatitis Due To Detergents

  • Irritant Contact Eczema Due To Solvents

  • Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants

  • Irritant Contact Eczema Due To Cosmetics Or Emollients

  • Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials

  • Irritant Contact Eczema Due To Plants Or Other Vegetable Matter

  • Irritant Contact Eczema Due To Foods

  • Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids

  • Irritant Contact Eczema Due To Saliva

  • Irritant Contact Eczema Due To Incontinence

  • Incontinence-Associated Dermatitis
Parasitic Ectoparasitic Infectious Disease

  • Ectoparasitic Infestations

  • Ectoparasitism
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Chronic Inducible Urticaria
Occupational Dermatitis

  • Dermatitis, Occupational

  • Occupational Allergic Contact Dermatitis

  • Occupational Eczema
Chronic Urticaria

  • Urticaria Chronic

  • Chronic Spontaneous Urticaria

  • Chronic Ordinary Urticaria
Fox-Fordyce Disease

  • Fox Fordyce Disease

  • Apocrine Miliaria

  • Fox-Fordyce Syndrome

  • Miliaria, Apocrine
Skin Atrophy

  • Atrophic Condition Of Skin

  • Atrophoderma

  • Atrophy - Skin
Luminal Breast Carcinoma B

  • Luminal B Breast Carcinoma
Nasopharyngitis

  • Chronic Nasopharyngitis

  • Chronic Rhinopharyngitis
Nasal Cavity Disease

  • Disorder Of Nasal Cavity
Nose Disease

  • Nose Diseases

  • Disorder Of The Nose

  • Nasal Disorder

  • Abnormality Of The Nose
Integumentary System Disease
Sezary'S Disease

  • Sezary Syndrome

  • Sézary Syndrome

  • Sezary'S Lymphoma

  • Sezary Disease

  • Sezary Erythroderma

  • Sezary Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-19522C Seladelpar (lysine dihydrate) 99.51% Unkown
阻害性抗体 (1)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-P99162 Nemolizumab Inhibitor 99.70% Unkown

Clinical Phase

阻害性抗体 (1)
製品番号 製品名 製品効果
純度 Phase
HY-P99519 Vixarelimab Inhibitor 96.90% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-145551 Atinvicitinib Inhibitor 98.62% Unkown
HY-170415 EGR-1-IN-3 Inhibitor 99.13% Unkown
HY-156959 Ovalicin Inhibitor / Unkown
HY-RS06754 IL31 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06755 IL31RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174609 Human IL31 mRNA / Unkown
HY-RS17747 Il31 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20557 Il31ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24213 Il31 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27066 Il31ra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P99301 Lokivetmab Inhibitor ≥99.0% Unkown
HY-P991280 BMS-981164 Inhibitor 95.36% Unkown
HY-P99557 Tirnovetmab Inhibitor 99.97% Unkown
HY-P990713 Nolavetbart 96% Unkown
HY-P992247 Anti-IL-31 Antibody / Unkown
HY-P99864 Dovanvetmab / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus IL31 VGNC VGNC:80444
Canis familiaris IL31 VGNC VGNC:41980
Macaca mulatta IL31 VGNC VGNC:108352
Mus musculus IL31 MGD MGI:1923649
Rattus norvegicus IL31 RGD RGD:1585183
Others IL31 NCBI