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IL20 - interleukin 20 Gene

Also Known as IL-20; IL10D; ZCYTO10

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 50604

About IL20

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,863,565-206,869,223 (from NCBI)

This gene has 3 transcripts (splice variants), 166 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

IL20 Products (4)

mRNA	Protein	Name
NM_001385165.1	NP_001372094.1	interleukin-20 isoform 2 precursor
NM_001385166.1	NP_001372095.1	interleukin-20 isoform 1 precursor
NM_001385167.1	NP_001372096.1	interleukin-20 isoform 1 precursor
NM_018724.4	NP_061194.2	interleukin-20 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	22802649	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL20 Protein Structure

IL10

0
100
176 a.a.

Protein Preferred Names	Protein Names
interleukin-20	cytokine Zcyto10

Recombinant IL20 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P7214	IL-20 Protein, Human	Q9NYY1-1 (L25-E176)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700111AF	Animal-Free IL-20 Protein, Human (His)	Q9NYY1-1 (L25-E176)	≥ 95%, as determined by reducing SDS-PAGE.

Diseases	Alias
Psoriasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Phase
HY-P99198	Fletikumab	Inhibitor	99.24%	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-106647	Abacavir hydroxyacetate	Inhibitor	99.61%	Unkown
HY-175813	NPSR1 antagonist-1		/	Unkown
HY-RS06698	IL17B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06731	IL20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06732	IL20RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06733	IL20RB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174623	Human IL20RA mRNA		/	Unkown
HY-174624	Human IL20 mRNA		/	Unkown
HY-RS18136	Il20 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21870	Il20ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24611	Il20 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28387	Il20ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown