CLDN9 - claudin 9 Gene

Also Known as DFNB116

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 9080

About CLDN9

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,012,923-3,014,505 (from NCBI)

This gene has 1 transcript (splice variant), 86 orthologues, 22 paralogues and is associated with 1 phenotype.

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010]

CLDN9 Products (1)

mRNA Protein Name
NM_020982.4 NP_066192.1 claudin-9

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
20375010 GOA
enables virus receptor activity IMP
IMP: Inferred from mutant phenotype
20375010 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in plasma membrane IDA
IDA: Inferred from direct assay
20375010 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
31175426 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN9 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (5 - 180)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

claudin-9

CLDN9 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CLDN9 O95484 GRM2 Homo sapiens Q14416
Validated Y2H
32296183
Intra
CLDN9 O95484 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
CLDN9 O95484 ADIPOQ Homo sapiens Q15848
Validated Y2H
32296183
Intra
CLDN9 O95484 ERMP1 Homo sapiens Q7Z2K6
Validated Y2H
32296183
Intra
CLDN9 O95484 PLPP6 Homo sapiens Q8IY26
Validated Y2H
32296183
Intra
CLDN9 O95484 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra
CLDN9 O95484 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra
CLDN9 O95484 VSTM1 Homo sapiens Q6UX27-3
Validated Y2H
32296183
Intra
CLDN9 O95484 PLPPR2 Homo sapiens Q96GM1
Y2H Array
32296183
Intra
CLDN9 O95484 PLPPR2 Homo sapiens Q96GM1
Y2H Prey Pooling
32296183
Intra
CLDN9 O95484 PLPPR2 Homo sapiens Q96GM1
Validated Y2H
32296183
Intra
CLDN9 O95484 EXTL1 Homo sapiens Q92935
Validated Y2H
32296183
Intra
CLDN9 O95484 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
Intra
CLDN9 O95484 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
CLDN9 O95484 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
CLDN9 O95484 AOC3 Homo sapiens Q16853
Validated Y2H
32296183
Intra
CLDN9 O95484 MAL Homo sapiens P21145
Validated Y2H
32296183
Intra
CLDN9 O95484 EMP1 Homo sapiens P54849
Validated Y2H
32296183
Intra
CLDN9 O95484 IGFBP5 Homo sapiens P24593
Validated Y2H
32296183
Intra
CLDN9 O95484 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra
CLDN9 O95484 BNIP3 Homo sapiens Q12983
Validated Y2H
32296183
Intra
CLDN9 O95484 MALL Homo sapiens Q13021
Validated Y2H
32296183
Intra
CLDN9 O95484 CYB561 Homo sapiens P49447
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLDN9 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P700407 Claudin-9/CLDN9 Protein-VLP, Human (HEK293, His) O95484 (M1-V217) Purity analysis by SDS-PAGE is not available for VLP proteins.

関連疾患

Diseases Alias
Deafness, Autosomal Recessive 116

  • DFNB116

  • Deafness, Autosomal Recessive, 116
Hepatitis C Virus

  • Hepatitis C Virus, Susceptibility To

  • Hepatitis C Virus Infection, Response To Therapy Of

  • Hcv

  • Hcv, Susceptibility To

  • Hepatitis C Virus, Resistance To

  • Hepatitis C Virus, Response To Therapy Of

  • Resistance To Hepatitis C Virus
Sacrum Chordoma
Hepatitis C

  • Chronic Hepatitis C

  • Hepatitis C Infection

  • Hepatitis Nona Nonb

  • Nanbh

  • Viral Hepatitis C

  • Hepatitis C Chronic

  • Hepatitis C, Chronic

  • Chronic Type C Viral Hepatitis

  • Chronic Hcv - [Hepatitis C Virus] Infection

  • Hepatitis C Nos

  • Hepatitis C Infection Nos

  • Hepatitis C-Related Cirrhosis

  • Type C Viral Hepatitis

  • Hep C Nos
Deafness, Autosomal Recessive 29

  • DFNB29

  • Autosomal Recessive Nonsyndromic Deafness 29

  • Autosomal Recessive Deafness 29

  • Deafness, Autosomal Recessive, 29

  • Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29

  • Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29

  • Deafness, Autosomal Recessive, Type 29
Hepatitis

  • Chronic Hepatitis

  • Chronic Persistent Hepatitis

  • Acute Hepatitis

  • Hepatitis, Chronic

  • Acute And Subacute Liver Necrosis

  • Acute/Subac. Necrosis Of Liver

  • Animal Hepatitis

  • Hepatitis Chronic

  • Hepatitis A

  • Hepatitis, Animal

  • Hepatitis Due To Toxoplasmosis

  • Hepatitis In Toxoplasmosis

  • Toxoplasmal Hepatitis

  • Chronic Hepatitis, Unspecified

  • Chronic Active Hepatitis Nec

  • Other Specified Chronic Hepatitis

  • Chronic Persistent Hepatitis Nec

  • Chronic Lobular Hepatitis Nec
Deafness, Autosomal Recessive 49

  • DFNB49

  • Autosomal Recessive Nonsyndromic Deafness 49

  • Autosomal Recessive Deafness 49

  • Deafness, Autosomal Recessive, 49

  • Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 49

  • Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 49

  • Deafness, Autosomal Recessive, Type 49
Deafness, Autosomal Recessive 86

  • DFNB86

  • Autosomal Recessive Nonsyndromic Deafness 86

  • Autosomal Recessive Deafness 86

  • Deafness, Autosomal Recessive, 86

  • Deafness, Nonsyndromic, Autosomal Recessive, Type 86
Sensorineural Hearing Loss

  • Sensory Hearing Loss

  • Sensorineural Deafness

  • Sensorineural Hearing Loss Disorder

  • Hearing Loss, Sensorineural

  • Central Hearing Loss

  • High Frequency Deafness

  • High Frequency Hearing Loss

  • High-Frequency Hearing Loss

  • Perceptive Deafness

  • Perceptive Hearing Loss

  • Perceptive Hearing Loss Or Deafness

  • Hearing Loss Sensorineural

  • Deafness Sensorineural

  • Hearing Loss High-Frequency

  • Hearing Loss, Central

  • Hearing Loss, High-Frequency
Autosomal Recessive Nonsyndromic Deafness

  • Deafness, Autosomal Recessive, Nonsyndromic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS02777 CLDN9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20380 Cldn9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26890 Cldn9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P992221 Anti-CLDN9 Antibody / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus CLDN9 VGNC VGNC:27420
Canis familiaris CLDN9 VGNC VGNC:39323
Rattus norvegicus CLDN9 RGD RGD:1308999
Felis catus CLDN9 VGNC VGNC:60939
Mus musculus CLDN9 MGD MGI:1913100
Others CLDN9 NCBI