EXTL1 - exostosin like glycosyltransferase 1 Gene

Also Known as EXTL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2134

Summary

This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors Alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. [provided by RefSeq, Jul 2008]
Biased expression in brain (RPKM 3.8), heart (RPKM 1.2) and 9 other tissues.

EXTL1 Products (1)

mRNA Protein Name
NM_004455.3 NP_004446.2 exostosin-like 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
11390981 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in heparan sulfate proteoglycan biosynthetic process IDA
IDA: Inferred from direct assay
11390981 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXTL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EXTL1 Q92935 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
EXTL1 Q92935 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
EXTL1 Q92935 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
EXTL1 Q92935 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
EXTL1 Q92935 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
EXTL1 Q92935 CLDN9 Homo sapiens O95484
Y2H Prey Pooling
32296183
Intra
EXTL1 Q92935 CLDN9 Homo sapiens O95484
Y2H Array
32296183
Intra
EXTL1 Q92935 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
EXTL1 Q92935 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
EXTL1 Q92935 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
EXTL1 Q92935 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
EXTL1 Q92935 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
EXTL1 Q92935 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04607 EXT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04610 EXTL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04609 EXTL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19000 Extl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21339 Ext1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21566 Extl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25489 Extl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27858 Ext1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28084 Extl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown