HEPES-d18
Based on 1 publication(s) in Google Scholar
HEPES-d18 is the deuterium labeled HEPES. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.89%
- CAS 番号: 203805-87-2
- 分子式: C8D18N2O4S
- 分子量:256.42
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 HEPES-d18
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生物活性
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 203805-87-2
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非標識Cas 7365-45-9
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性状 Solid
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分子量 256.42
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分子式 C8D18N2O4S
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Color White to off-white
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SMILES
O=S(C([2H])([2H])C([2H])([2H])N1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])O[2H])(O[2H])=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Development of pH-adjusted NMR methodology for quantitation of caffeoylquinic acid derivatives and evaluation of their antimalignant pleural mesothelioma potential. [Abstract]2025 Jul 15:259:116776. PMID: 40024029
溶剤 & 溶解度
H2O : 100 mg/mL (389.99 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [Content Brief]
[3]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 201066(Pt 4):482-492. [Content Brief]
[4]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 201814(3):437-449. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.8999 mL | 19.4993 mL | 38.9985 mL | 97.4963 mL |
| 5 mM | 0.7800 mL | 3.8999 mL | 7.7997 mL | 19.4993 mL | |
| 10 mM | 0.3900 mL | 1.9499 mL | 3.8999 mL | 9.7496 mL | |
| 15 mM | 0.2600 mL | 1.3000 mL | 2.5999 mL | 6.4998 mL | |
| 20 mM | 0.1950 mL | 0.9750 mL | 1.9499 mL | 4.8748 mL | |
| 25 mM | 0.1560 mL | 0.7800 mL | 1.5599 mL | 3.8999 mL | |
| 30 mM | 0.1300 mL | 0.6500 mL | 1.3000 mL | 3.2499 mL | |
| 40 mM | 0.0975 mL | 0.4875 mL | 0.9750 mL | 2.4374 mL | |
| 50 mM | 0.0780 mL | 0.3900 mL | 0.7800 mL | 1.9499 mL | |
| 60 mM | 0.0650 mL | 0.3250 mL | 0.6500 mL | 1.6249 mL | |
| 80 mM | 0.0487 mL | 0.2437 mL | 0.4875 mL | 1.2187 mL | |
| 100 mM | 0.0390 mL | 0.1950 mL | 0.3900 mL | 0.9750 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
HEPES-d18 関連分類
HY-D0857S 関連分類
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