Homopterocarpin
Based on 1 Customer Validation
Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective, antioxidant and antiplasmodial activity. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC50 and a Ki of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 606-91-7
- 分子式: C17H16O4
- 分子量:284.31
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
|
Plasmodium |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
5.2 μg/mL
Compound: 3, homopterocarpin
|
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
|
[PMID: 15787450] |
| CCRF-CEM | IC50 |
5.5 μg/mL
Compound: 3, homopterocarpin
|
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
|
[PMID: 15787450] |
| HCT-8 | IC50 |
6.4 μg/mL
Compound: 3, homopterocarpin
|
Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
|
[PMID: 15787450] |
| HL-60 | IC50 |
3.9 μg/mL
Compound: 3, homopterocarpin
|
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
|
[PMID: 15787450] |
| MCF7 | IC50 |
18.5 μg/mL
Compound: 3, homopterocarpin
|
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 15787450] |
| U-937 | IC50 |
>100 μM
Compound: 18, homopterocarpin
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Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
|
[PMID: 17158054] |
| U-937 | IC50 |
>100 μM
Compound: 18, homopterocarpin
|
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
|
[PMID: 17158054] |
| U-937 | IC50 |
>100 μM
Compound: 18, homopterocarpin
|
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
|
[PMID: 17158054] |
化学情報
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CAS 番号 606-91-7
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性状 Solid
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分子量 284.31
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分子式 C17H16O4
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SMILES
COC1=CC=C([C@@]2([H])[C@@](C3=CC=C(OC)C=C3O2)([H])CO4)C4=C1
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別名
(-)-Homopterocarpin; 3,9-Dimethoxypterocarpan
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
参考文献
[1]. Akinmoladun AC, et al. Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity. J Basic Clin Physiol Pharmacol. 2015 Nov;26(6):555-62. [Content Brief]
[2]. Oh JM, et al. Medicarpin and Homopterocarpin Isolated from Canavalia lineata as Potent and Competitive Reversible Inhibitors of Human Monoamine Oxidase-B. Molecules. 2022 Dec 28;28(1):258. [Content Brief]
[3]. Alsaleem MA, et al. Homopterocarpin alleviates methoxychlor-induced hepatotoxicity via modulating thioredoxin/peroxiredoxin and TLR4/MyD88 pathway: A comprehensive biochemical, histopathological, and computational analysis. Tissue Cell. 2026;98:103174. [Content Brief]
[4]. Wahyuni DK, et al. In silico anti-SARS-CoV-2, antiplasmodial, antioxidant, and antimicrobial activities of crude extracts and homopterocarpin from heartwood of Pterocarpus macrocarpus Kurz. Heliyon. 2023;9(2):e13644. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Homopterocarpin 関連分類
HY-N4037 関連分類
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