JMV 449
JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.15 nM for inhibition of [125I]-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 139026-66-7
- 分子式: C38H66N8O7
- 分子量:746.98
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-P0234
NeurotensinNeurotensin Receptor Agonist -
HY-P1255
KinetensinEndogenous Metabolite -
HY-107664
SR 142948NT Antagonist -
HY-P0251
Neurotensin(8-13)Neurotensin Receptor Agonist -
HY-125880
SBI-553NTR1 Allosteric Modulator -
![[Lys8, Lys9]-Neurotensin (8-13)](https://file.medchemexpress.com/product_pic/hy-p2544.gif)
HY-P2544
[Lys8, Lys9]-Neurotensin (8-13) -
HY-115213
SORT-PGRN interaction inhibitor 1Sortilin-Progranulin Interaction Inhibitor -
HY-107664R
SR 142948 (Standard)Reference Standard -
HY-P1257
Xenin-8Insulin Secretagogue -
HY-16639
ML314NTR1 Activator -
HY-12436
NTRC-824NTS2 Antagonist -
![[D-Trp11]-Neurotensin](https://file.medchemexpress.com/product_pic/hy-p3057.gif)
HY-P3057
[D-Trp11]-NeurotensinNeurotensin Receptor Modulator
生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss albino mice[2]
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Dosage:120 pmol/mouse
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Administration:i.c.v.
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Result:Showed dose-response relation-ships for the analgesic effect.
化学情報
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CAS 番号 139026-66-7
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分子量 746.98
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分子式 C38H66N8O7
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198. [Content Brief]
[2]. Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
JMV 449 関連分類
HY-P1256 関連分類
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