LIMK-IN-1
Based on 1 Customer Validation
LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.33%
- CAS 番号: 1116571-01-7
- 分子式: C20H21BrN8
- 分子量:453.34
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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LIMK1 0.9 nM (IC50) |
LIMK2 0.5 nM (IC50) |
ROCK1 260 nM (IC50) |
ROCK2 2700 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.9 nM
Compound: 14
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Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation counting
Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation counting
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[PMID: 19831390] |
LIMK-IN-1 (Compound 14) (100 nM) increases outflow facility by about 30% in a pig eye perfusion assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1116571-01-7
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性状 Solid
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分子量 453.34
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分子式 C20H21BrN8
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Color White to off-white
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SMILES
CC1=CNC2=NC=NC(N3C[C@H](C)N(/C(NC4=CC=CC(Br)=C4)=N\C#N)CC3)=C21
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 125 mg/mL (275.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
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- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2058 mL | 11.0292 mL | 22.0585 mL | 55.1462 mL |
| 5 mM | 0.4412 mL | 2.2058 mL | 4.4117 mL | 11.0292 mL | |
| 10 mM | 0.2206 mL | 1.1029 mL | 2.2058 mL | 5.5146 mL | |
| 15 mM | 0.1471 mL | 0.7353 mL | 1.4706 mL | 3.6764 mL | |
| 20 mM | 0.1103 mL | 0.5515 mL | 1.1029 mL | 2.7573 mL | |
| 25 mM | 0.0882 mL | 0.4412 mL | 0.8823 mL | 2.2058 mL | |
| 30 mM | 0.0735 mL | 0.3676 mL | 0.7353 mL | 1.8382 mL | |
| 40 mM | 0.0551 mL | 0.2757 mL | 0.5515 mL | 1.3787 mL | |
| 50 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1029 mL | |
| 60 mM | 0.0368 mL | 0.1838 mL | 0.3676 mL | 0.9191 mL | |
| 80 mM | 0.0276 mL | 0.1379 mL | 0.2757 mL | 0.6893 mL | |
| 100 mM | 0.0221 mL | 0.1103 mL | 0.2206 mL | 0.5515 mL |
LIMK-IN-1 関連分類
HY-14227 関連分類
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