Lipid-lowering agent-2
Lipid-lowering agent-2 (Compound 14d) is an orally active lipid-lowering agent with an EC50 of 0.06 μM. Lipid-lowering agent-2 inhibits the lipid synthesis, activates the AMPK signaling pathway, and exhibits anti-obesity effect. Lipid-lowering agent-2 inhibits food intake, improves the glucose metabolism, and reduces the body weight and adipose tissue in high-fat diet (HFD)-induced obese mice.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C25H27N7O
- 分子量:441.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
AMPK アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | CC50 |
34.3 μM
Compound: 14d
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Cytotoxicity against confluent mouse 3T3-L1 preadipocytes assessed as reduction in cell viability measured after 24 hrs by SRB method
Cytotoxicity against confluent mouse 3T3-L1 preadipocytes assessed as reduction in cell viability measured after 24 hrs by SRB method
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[PMID: 38996004] |
| 3T3-L1 | EC50 |
0.06 μM
Compound: 14d
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Lipid lowering activity in confluent mouse 3T3-L1 preadipocytes assessed as reduction in triglyceride level incubated for 9 days by oil red o staining based analysis
Lipid lowering activity in confluent mouse 3T3-L1 preadipocytes assessed as reduction in triglyceride level incubated for 9 days by oil red o staining based analysis
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[PMID: 38996004] |
化学情報
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分子量 441.53
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分子式 C25H27N7O
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SMILES
O=C(N/N=C/C1=C(NC2=CC=CC=C21)C3=NC4=C(C(NCCN5CCCC5)=N3)C=CC=C4)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)