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製品番号: HY-148574

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MCT1-IN-3

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Based on 1 Customer Validation

MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC₅₀ value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer.

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純度: 98.65%
CAS 番号: 2878360-80-4
分子式: C₂₂H₁₉N₃O₄
分子量:389.40

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

MCT1-IN-3 構造式

CAS 番号: 2878360-80-4

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

IC50: 81.0 nM (MCT1)^[1]
GI50: 20 μM (A-549); 15.1 μM (MCF-7)^[1]

Monocarboxylate Transporter アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780 ADR	EC₅₀	0.793 μM Compound: 24	Reversal of multi-drug resistance in human A2780 ADR cells expressing ABCB1 incubated for 72 hrs by MTT assay Reversal of multi-drug resistance in human A2780 ADR cells expressing ABCB1 incubated for 72 hrs by MTT assay	[PMID: 36584238]
A2780 ADR	GI₅₀	110 nM Compound: 24	Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 3.5 uM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 3.5 uM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A2780 ADR	GI₅₀	214 nM Compound: 24	Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 2 uM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 2 uM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A2780 ADR	GI₅₀	32.2 nM Compound: 24	Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 5 uM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 5 uM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A2780 ADR	GI₅₀	332 nM Compound: 24	Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 1 uM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 1 uM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A549	GI₅₀	19.4 nM Compound: 24	Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin IC50 at 500 nM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin IC50 at 500 nM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A549	GI₅₀	20 μM Compound: 24	Antiproliferative activity against human A549 cells expressing MCT1 assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells expressing MCT1 assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 36584238]
A549	GI₅₀	27.7 nM Compound: 24	Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin GI50 at 100 nM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin GI50 at 100 nM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A549	GI₅₀	40 nM Compound: 24	Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin GI50 at 50 nM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin GI50 at 50 nM incubated for 72 hrs by MTT assay	[PMID: 36584238]
MCF7	GI₅₀	15.1 μM Compound: 24	Antiproliferative activity against human MCF7 cells expressing MCT1 assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells expressing MCT1 assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 36584238]

体外実験

MCT1-IN-3 (compound 24) has inhibitory activity for MCT1 with an IC₅₀ value of 81.0 nM^[1].
MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI₅₀ values of 20 μM and 15.1 μM, respectively^[1].
MCT1-IN-3 (5 μM; 24 h) leads to cancer cell cycle arrest as well as apoptosis^[1].
MCT1-IN-3 (1.0, 2.0, 3.5, and 5.0 μM) shows to sensitize these cancer cells toward an antineoplastic agent^[1].
MCT1-IN-3 has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

A-549 cells
Concentration:

5 μM
Incubation Time:

24 h
Result:

Caused a disruption of the cell cycle of A-549 cancer cells, indicated by a shift from the predominant Go/G, phase.

Apoptosis Analysis^[1]

Cell Line:

A-549 cells
Concentration:

5 μM
Incubation Time:

24 h
Result:

Increased the percentage of total apoptotic cells by a factor of 13 from 0.51 to 6.68%.

化学情報

CAS 番号 2878360-80-4
性状 Solid
分子量 389.40
分子式 C₂₂H₁₉N₃O₄
Color Off-white to light yellow
SMILES

COC(/C(C#N)=C/C1=CN(C2=CC=CC=C12)CC(NC3=CC=C(C=C3)OC)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sachin Puri, et al. Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1). J Med Chem. 2023 Jan 12;66(1):657-676. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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MCT1-IN-3

Anti-Cancer Metabolism Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Anti-Drug-Resistant Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Membrane Transporter/Ion Channel Compound Library

Anti-Cancer Compound Library

Monocarboxylate Transporter アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

MCT1-IN-3

Anti-Cancer Metabolism Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Anti-Drug-Resistant Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Membrane Transporter/Ion Channel Compound Library

Anti-Cancer Compound Library

Monocarboxylate Transporter アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

MCT1-IN-3 関連分類

HY-148574 関連分類