Olmutinib hydrochloride
Based on 12 publication(s) in Google Scholar
Olmutinib hydrochloride is an orally active and irreversible third EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain. Olmutinib hydrochloride is used for NSCLC.
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- CAS 番号: 1842366-97-5
- 分子式: C26H28Cl2N6O2S
- 分子量:559.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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MedChemExpress（MCE）の使用を引用している文献 Olmutinib hydrochloride
More- Acta Pharm Sin B. 2018 Jul;8(4):563-574. [Abstract]
- J Pharm Anal. 2021 Dec;11(6):799-807. [Abstract]
- Mol Syst Biol. 2024 Jan;20(1):28-55. [Abstract]
- RSC Adv. 2018 Dec 4;8(70):40387-40394. [Abstract]
- Rheumatology (Oxford). 2025 Aug 13:keaf437. [Abstract]
- Biomedicines. 2024 Jan 7;12(1):123. [Abstract]
- J Sep Sci. 2020 Feb;43(4):708-718. [Abstract]
- Biochem Biophys Res Commun. 2026 Feb 12:800:153165.
- J Biomol Struct Dyn. 2022;40(24):14236-14246. [Abstract]
- Med Sci Monit. 2020 Aug 24:26:e924922. [Abstract]
- bioRxiv. 2026 May 8:2026.05.05.723030. [Abstract]
- Patent. US20220177473A1.
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生物活性
化学情報
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CAS 番号 1842366-97-5
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分子量 559.51
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分子式 C26H28Cl2N6O2S
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SMILES
O=C(NC1=CC(OC2=NC(NC3=CC=C(N4CCN(CC4)C)C=C3)=NC5=C2SC=C5)=CC=C1)C=C.Cl.Cl
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別名
HM61713 hydrochloride; BI 1482694 hydrochloride
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (12)
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Journal Impact Factor
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Most Recent
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Acta Pharm Sin B
Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATP-binding cassette subfamily G member 2 in vitro and in vivo. [Abstract]2018 Jul;8(4):563-574. PMID: 30109181
Olmutinib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2018 Jul;8(4):563-574. [Abstract]
The protein levels of ABCG2 in MDR cells after different concentrations Olmutinib stimulation for 48 h are measured by Western blot analysis (GAPDH as loading control).
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J Pharm Anal
Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells. [Abstract]2021 Dec;11(6):799-807. PMID: 35028186 -
Mol Syst Biol
Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics. [Abstract]2024 Jan;20(1):28-55. PMID: 38177929 -
RSC Adv
Investigation of the metabolic stability of olmutinib by validated LC-MS/MS: quantification in human plasma. [Abstract]2018 Dec 4;8(70):40387-40394. PMID: 35558213 -
Rheumatology (Oxford)
Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence. [Abstract]2025 Aug 13:keaf437. PMID: 40802538 -
Biomedicines
Extracellular Vesicles and Exosomes: Novel Insights and Perspectives on Lung Cancer from Early Detection to Targeted Treatment. [Abstract]2024 Jan 7;12(1):123. PMID: 38255228 -
J Sep Sci
Detection and characterization of olmutinib reactive metabolites by LC-MS/MS: Elucidation of bioactivation pathways. [Abstract]2020 Feb;43(4):708-718. PMID: 31788977 -
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J Biomol Struct Dyn
Spectroscopic, molecular docking and dynamic simulation studies of binding between the new anticancer agent olmutinib and human serum albumin. [Abstract]2022;40(24):14236-14246. PMID: 34766879 -
Med Sci Monit
2020 Aug 24:26:e924922. PMID: 32830792 -
bioRxiv
2026 May 8:2026.05.05.723030. PMID: 42146668 -
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Olmutinib hydrochloride 関連分類
HY-19730A 関連分類
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