OSE-279
OSE-279 is a high-affinity humanized monoclonal bivalent antibody targeting PD-1, the recommended isotype control is HY-P99003. OSE-279 blocks PD-1 ligand binding, inhibits PDL1-induced SHP1 phosphorylation, restores T cell activation, and promotes reactivation of primary T cell effector functions. OSE-279 binds hFcRn receptor, predicts long half-life, induces CD4 and CD8 T cell proliferation, and promotes interleukin 2 and interferon gamma secretion. OSE-279 can be used for the research of advanced malignancies, colon cancer, hepatocarcinoma, mesothelioma.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Human IgG4 kappa
Human
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IL-2 |
OSE-279 blocks PD-1 binding to PD-L1 with an IC50 of 308 ng/mL and to PD-L2 with an IC50 of 911 ng/mL in cell-free binding assays[2].
OSE-279 inhibits PD-L1-induced SHP1 phosphorylation in a cell-based assay with an IC50 of 14.19 ng/mL[1].
OSE-279 reactivates primary T cell effector functions in an MLR assay, inducing interleukin 2 and interferon γ secretion[1].
OSE-279 shows good affinity to the human FcRn receptor, predicting a long half-life in humans[1].
OSE-279 restores T cell activation via inhibition of pSHP-1 signalling in cell-based assayS[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PDCD1/PD-1/CD279
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
化学情報
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
OSE-279 関連分類
HY-P992434 関連分類
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