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Perenostobart

(別名: SRF617)
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Based on 1 Customer Validation

Perenostobart (SRF617) is a human IgG4 antibody with inhibitory activity against CD39 ATPase. Perenostobart inhibits CD39-mediated hydrolysis of extracellular ATP to AMP, with IC50 values of 1.9 nM (HEK293 OE cells), 0.7 nM (MOLP-8 cells), and 1.2 nM (RBC-lysed whole blood). Perenostobart enhances CD4+ T-cell proliferation, promotes dendritic cell maturation, and boosts inflammasome activation in macrophages in the presence of ATP. Perenostobart demonstrates significant single-agent anti-tumor efficacy in MOLP-8 and H520 xenograft models. Perenostobart can be used for the study of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 97.00%
  • CAS 番号: 2643331-31-9
  • 分子量:145.5 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Perenostobart
  • Experimental Validation Results for Perenostobart
  • Experimental Validation Results for Perenostobart
  • Perenostobart Chemical Structure
    Perenostobart 構造式
CAS 番号: 2643331-31-9
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Loaded Perenostobart on AHC2 biosensor, can bind CD39 Protein, Human (sf9, His, HY-P75417) with an affinity constant of 3.546E-09 M as determined in BLI assay.

  • 1/16

    Flow Cytometry analysis of Raji cells labelling ENTPD1/CD39 (red) with Perenostobart (anti-ENTPD1/CD39) (HY-P990068). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG4 kappa (HY-P99003). Black-Unlabelled control, cells without incubation with primary antibody.

  • Perenostobart Chemical Structure
    1/16
  • Perenostobart
  • Loaded Perenostobart on AHC2 biosensor, can bind CD39 Protein, Human (sf9, His, HY-P75417) with an affinity constant of 3.546E-09 M as determined in BLI assay.
  • Flow Cytometry analysis of Raji cells labelling ENTPD1/CD39 (red) with Perenostobart (anti-ENTPD1/CD39) (HY-P990068). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG4 kappa (HY-P99003). Black-Unlabelled control, cells without incubation with primary antibody.