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製品番号: HY-N8255

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Puupehenone

Puupehenone is a cytotoxic and antifungal agent present in various marine sponge species. Puupehenone exerts cytotoxic activity against leukemia, lung cancer, colon cancer and breast cancer cells, and inhibits the growth of Candida albicans. Puupehenone can be used in research related to cancers such as leukemia, lung cancer, colon cancer and breast cancer.

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CAS 番号: 73573-17-8
分子式: C₂₁H₂₈O₃
分子量:328.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Puupehenone 構造式

CAS 番号: 73573-17-8

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生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	EC₅₀	3.3 μM Compound: 6	Inhibition of HIF2alpha in human 786-0 cells expressing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter gene assay Inhibition of HIF2alpha in human 786-0 cells expressing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter gene assay	[PMID: 22928967]
786-0	IC₅₀	17.7 μM Compound: 6	Cytotoxicity against human 786-0 cells expressing HIF2alpha after 2 days by XTT assay Cytotoxicity against human 786-0 cells expressing HIF2alpha after 2 days by XTT assay	[PMID: 22928967]
A549	IC₅₀	0.1 μg/mL Compound: 1	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 3655802]
A549	IC₅₀	0.4 μg/mL Compound: Puupehenone	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 8350092]
HCT-8	IC₅₀	1 μg/mL Compound: 1	Cytotoxicity against human HCT8 cells Cytotoxicity against human HCT8 cells	[PMID: 3655802]
HL-60	IC₅₀	27 μM Compound: 5	Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay	[PMID: 12762791]
HT-29	IC₅₀	0.2 μg/mL Compound: Puupehenone	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 8350092]
KB	IC₅₀	0.5 μg/mL Compound: 1	Cytotoxicity against human KB cells by neutral red assay Cytotoxicity against human KB cells by neutral red assay	[PMID: 10514320]
MCF7	IC₅₀	0.1 μg/mL Compound: 1	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 3655802]
P388	IC₅₀	1 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 3655802]
P388	IC₅₀	1.3 μg/mL Compound: Puupehenone	Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay	[PMID: 8350092]
RCC4	IC₅₀	18 μM Compound: 6	Cytotoxicity against human RCC4 cells expressing HIF2alpha and HIF1alpha after 2 days by XTT assay Cytotoxicity against human RCC4 cells expressing HIF2alpha and HIF1alpha after 2 days by XTT assay	[PMID: 22928967]

体外実験

Puupehenone is the major metabolite isolated from two unreported Hawaiian sponges of the genus *Hyrtios*, and its structure is confirmed by comparison of NMR spectra with a standard reference substance^[1].
Puupehenone exhibits cytotoxicity against P388 mouse leukemia cells, A-549 human lung cancer cells, HCT-8 human colon cancer cells, and MCF-7 human breast cancer cells in vitro^[2].
Puupehenone inhibits the growth of Candida albicans in vitro, with a minimum inhibitory concentration of 3 μg/mL^[2].
Puupehenone (compound 1) (serial dilution; 3 days) weakly inhibits the growth of bovine aortic endothelial cells and various human tumor cell lines, with IC₅₀ values ranging from 5 μM to >15 μM, and shows no selectivity for endothelial cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Puupehenone (25 mg/kg; daily; 9 days) produces a T/C value of 119 in the P388 mouse leukemia in vivo model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 73573-17-8
分子量 328.45
分子式 C₂₁H₂₈O₃
SMILES

C[C@@]12[C@@]3([C@@](C)(OC=4C(=C3)C=C(O)C(=O)C4)CC[C@]1(C(C)(C)CCC2)[H])[H]
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Marine natural products
- Sponge
marine sponge Hyrtios sp.
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Nasu SS, et al. Puupehenone-related metabolites from two Hawaiian sponges, Hyrtios spp. J Org Chem. 1995 Nov 1;60(22):7290-7292.

[2]. Kohmoto S, et al. Puupehenone, A Cytotoxic Metabolite from a Deep Water Marine Sponge, Stronglyophora hartmani. J Nat Prod. 1987 Mar 1;50(2):336.

[3]. Castro ME, et al. Study of puupehenone and related compounds as inhibitors of angiogenesis. Int J Cancer. 2004;110(1):31-38. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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