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製品番号: HY-P99404

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Biologically Validated

Quetmolimab

(別名: E6011)

カスタマーレビュー

Based on 1 Customer Validation

Quetmolimab (E6011) is a humanized anti-Fractalkine (CX3CL1) monoclonal antibody. Quetmolimab binds to membrane-bound and soluble Fractalkine, neutralizes Fractalkine-induced migration of CX3CR1-expressing cells, mediates target-bound complex elimination from serum. Quetmolimab suppresses free soluble Fractalkine levels in cynomolgus monkeys, with target engagement linked to increased serum total Fractalkine concentration. Quetmolimab can be used for the research of Crohn’s disease, rheumatoid arthritis, and primary biliary cholangitis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.9%
CAS 番号: 2084037-83-0
分子量:144.72 kDa

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Quetmolimab 構造式

CAS 番号: 2084037-83-0

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 体内実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
- Verified Bioactivity
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Isotype

Human IgG2 kappa

Recommend Isotype Controls

Human IgG2 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CX3CL1/Fractalkine

CXCR アイソフォーム固有の製品をすべて表示 :

体外実験

Quetmolimab (E6011) inhibits fractalkine-induced migration of human CX3CR1-transfected B300.19 mouse B-lymphocyte precursors, with a minimum active concentration of 3.2 ng/mL for 10% maximal suppression of free soluble FKN from baseline^[1].
Quetmolimab binds to soluble human fractalkine with a mean equilibrium dissociation constant of 0.27 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Quetmolimab (E6011) (0.05-100 mg/kg; i.v.; single infusion) at doses from 0.05 to 100 mg/kg in cynomolgus monkeys engages its target (fractalkine) as confirmed by increased total serum FKN concentrations, with a near-complete maximum effect (E_MAX = 0.974) on modulating free soluble FKN elimination^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Cynomolgus monkeys (median body weight 3.44 kg)^[1]
Dosage:

0.05-100 mg/kg
Administration:

i.v.; single infusion
Result:

Exhibited a triphasic elimination profile, with dose-dependent increases in exposure where area under the concentration-time curve (AUC) increased more than proportionally to dose.
Increased serum total FKN concentration, confirming target engagement.
Reached a maximum effect (EMAX) of 0.974, indicating near-complete suppression of free soluble FKN elimination at sufficient concentrations.

遺伝子ID

6376 [NCBI]

アクセッション番号

P78423

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG2 kappa

アプリケーション

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Fractalkine/CX3CL1 Protein, Human (HY-P7180) can bind Quetmolimab. The EC₅₀ for this effect is 3.65 ng/mL.

化学情報

CAS 番号 2084037-83-0
性状 Liquid
分子量 144.72 kDa
Color Colorless to light yellow
SMILES

[Quetmolimab]
別名

E6011
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (260 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Tabuchi H, et al. Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study. J Clin Pharmacol. 2019;59(5):688-701. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 体内実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
- Biological Activity
化学情報
純度とドキュメンテーション
参考文献

製品名:
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数量:
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製品名:
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Quetmolimab

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Antibody Inhibitor Library

CXCR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Quetmolimab 関連分類

HY-P99404 関連分類