Ro 24-5913
Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 128312-51-6
- 分子式: C23H28N2O3S
- 分子量:412.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: 6.4 nM (LTD4)[1]
Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50 value of 6.4 nM[1]. Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKB value of 9.3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Guinea pigs[1]
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Dosage:10 mg/kg
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Administration:Oral gavage; 10 mg/kg once
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Result:Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs.
化学情報
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CAS 番号 128312-51-6
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分子量 412.55
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分子式 C23H28N2O3S
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SMILES
OC(C(CC)(CC)CC(NC1=CC=CC(/C=C/C2=NC(C3CCC3)=CS2)=C1)=O)=O
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別名
Cinalukast
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ro 24-5913 関連分類
HY-107611 関連分類
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