(S)-Malic acid-d3
Based on 1 publication(s) in Google Scholar
(S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.64%
- CAS 番号: 59652-74-3
- 分子式: C4H3D3O5
- 分子量:137.11
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 (S)-Malic acid-d3
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生物活性
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 59652-74-3
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非標識Cas 97-67-6
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性状 Solid
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分子量 137.11
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分子式 C4H3D3O5
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Color White to off-white
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SMILES
O=C(O)C([2H])([2H])[C@]([2H])(O)C(O)=O
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別名
(S)-Hydroxybutanedioic acid-d3; (S)-E 296-d3; L-Malic acid-d3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
2024 Dec 30;9(1):367. PMID: 39737965
溶剤 & 溶解度
DMSO : 100 mg/mL (729.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (729.34 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Landete JM, et al. Requirement of the Lactobacillus casei MaeKR two-component system for L-malic acid utilization via a malic enzyme pathway. Appl Environ Microbiol. 2010 Jan;76(1):84-95. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 7.2934 mL | 36.4671 mL | 72.9341 mL | 182.3354 mL |
| 5 mM | 1.4587 mL | 7.2934 mL | 14.5868 mL | 36.4671 mL | |
| 10 mM | 0.7293 mL | 3.6467 mL | 7.2934 mL | 18.2335 mL | |
| 15 mM | 0.4862 mL | 2.4311 mL | 4.8623 mL | 12.1557 mL | |
| 20 mM | 0.3647 mL | 1.8234 mL | 3.6467 mL | 9.1168 mL | |
| 25 mM | 0.2917 mL | 1.4587 mL | 2.9174 mL | 7.2934 mL | |
| 30 mM | 0.2431 mL | 1.2156 mL | 2.4311 mL | 6.0778 mL | |
| 40 mM | 0.1823 mL | 0.9117 mL | 1.8234 mL | 4.5584 mL | |
| 50 mM | 0.1459 mL | 0.7293 mL | 1.4587 mL | 3.6467 mL | |
| 60 mM | 0.1216 mL | 0.6078 mL | 1.2156 mL | 3.0389 mL | |
| 80 mM | 0.0912 mL | 0.4558 mL | 0.9117 mL | 2.2792 mL | |
| 100 mM | 0.0729 mL | 0.3647 mL | 0.7293 mL | 1.8234 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S)-Malic acid-d3 関連分類
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