Succinic acid-d4
Based on 1 publication(s) in Google Scholar
Succinic-2,2,3,3-d4 acid is the deuterium labeled Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 14493-42-6
- Formula: C4H2D4O4
- Molecular Weight:122.11
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Succinic acid-d4
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 14493-42-6
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Unlabeled Cas 110-15-6
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Appearance Solid
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Molecular Weight 122.11
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Formula C4H2D4O4
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Color White to off-white
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SMILES
O=C(O)C([2H])([2H])C([2H])([2H])C(O)=O
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Synonyms
Wormwood acid-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Development of new liquid chromatography-tandem mass spectrometry methods for the quantification of seven metabolites in three related breast cancer cell lines. [Abstract]2026 Jun 13:280:117612. PMID: 42320281
Solvent & Solubility
H2O : 100 mg/mL (818.93 mM; Need ultrasonic)
DMSO : 100 mg/mL (818.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 8.1893 mL | 40.9467 mL | 81.8934 mL | 204.7334 mL |
| 5 mM | 1.6379 mL | 8.1893 mL | 16.3787 mL | 40.9467 mL | |
| 10 mM | 0.8189 mL | 4.0947 mL | 8.1893 mL | 20.4733 mL | |
| 15 mM | 0.5460 mL | 2.7298 mL | 5.4596 mL | 13.6489 mL | |
| 20 mM | 0.4095 mL | 2.0473 mL | 4.0947 mL | 10.2367 mL | |
| 25 mM | 0.3276 mL | 1.6379 mL | 3.2757 mL | 8.1893 mL | |
| 30 mM | 0.2730 mL | 1.3649 mL | 2.7298 mL | 6.8244 mL | |
| 40 mM | 0.2047 mL | 1.0237 mL | 2.0473 mL | 5.1183 mL | |
| 50 mM | 0.1638 mL | 0.8189 mL | 1.6379 mL | 4.0947 mL | |
| 60 mM | 0.1365 mL | 0.6824 mL | 1.3649 mL | 3.4122 mL | |
| 80 mM | 0.1024 mL | 0.5118 mL | 1.0237 mL | 2.5592 mL | |
| 100 mM | 0.0819 mL | 0.4095 mL | 0.8189 mL | 2.0473 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Succinic acid-d4 Related Classifications
HY-N0420S1 Related Classifications
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