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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
Notum
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "Notum" in MCE Product Catalog:
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1 Cited Publications
LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats .
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ARUK3001185 is a potent, selective, orally active and brain-penetrant inhibitor of Notum (IC50 = 6.7 nM). ARUK3001185 can restore Wnt signaling in the presence of Notum in vitro. ARUK3001185 is selective against serine hydrolases, kinases, and drug targets. ARUK3001185 can be used to research the role of Notum plays in diseases .
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研究分野:
Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease .
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研究分野:
Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease .
製品番号: HY-W171983
CAS 番号: 338419-11-7
Notum-IN-1 (compound 6b) is an orally active, selective and brain penetrant inhibitor of Notum. Notum-IN-1 blocks the Wnt signaling in vivo in mouse .
製品番号: HY-148360
CAS 番号: 460727-10-0
Target:
研究分野:
Notum pectinacetylesterase-1 is a potent inhibitor of notum pectinacetylesterase. Notum pectinacetylesterase-1 can be used for the research of disorders affecting the bone .
製品番号: HY-RS09454
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研究分野:
NOTUM Human Pre-designed siRNA Set A contains three designed siRNAs for NOTUM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS21001
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研究分野:
Notum Mouse Pre-designed siRNA Set A contains three designed siRNAs for Notum gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-182402
CAS 番号: 2411969-28-1
Target:
Notum-IN-2 is a partially brain-penetrant Notum carboxyl-esterase inhibitor with an IC50 of 18 nM. Notum-IN-2 can be used as a chemical tool for exploring Wnt signalling in cells .
製品番号: HY-RS27518
Target:
研究分野:
Notum Rat Pre-designed siRNA Set A contains three designed siRNAs for Notum gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-182632
CAS 番号: 1875037-24-3
Target:
研究分野:
LP-935001 is a Notum carboxylesterase inhibitor with an IC50 of 0.4 nM.LP-935001 prevents palmitoleate group removal from Wnt proteins, restores Wnt/β-catenin signaling.LP-935001 enhances cortical bone thickness in rodent models.LP-935001 can be used for the research of bone loss/nonvertebral fractures .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
