ARUK3001185
Based on 1 Customer Validation
ARUK3001185 is a potent, selective, orally active and brain-penetrant inhibitor of Notum (IC50 = 6.7 nM). ARUK3001185 can restore Wnt signaling in the presence of Notum in vitro. ARUK3001185 is selective against serine hydrolases, kinases, and drug targets. ARUK3001185 can be used to research the role of Notum plays in diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.28%
- CAS 番号: 2411969-39-4
- 分子式: C9H4Cl2F3N3
- 分子量:282.05
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Stem Cell Signaling Compound Library
HY-L017
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Wnt/Hedgehog/Notch Compound Library
HY-L020
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Anti-Cancer Compound Library
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CNS-Penetrant Compound Library
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Anti-Aging Compound Library
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Reprogramming Compound Library
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Cytoskeleton Compound Library
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Orally Active Compound Library
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Neuroprotective Compound Library
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Anti-Obesity Compound Library
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Antidepressant Compound Library
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Osteogenesis Compound Library
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Highly Selective Activators Library
HY-L159
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Extracellular Vesicles (EVs) Compound Library
HY-L168
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
IC50: 6.7 nM (Notum)[1]
ARUK3001185 inhibits Notum with an IC50 of 6.7 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2411969-39-4
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性状 Solid
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分子量 282.05
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分子式 C9H4Cl2F3N3
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Color Off-white to pink
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SMILES
FC(F)(C1=C(Cl)C=CC(N2C=CN=N2)=C1Cl)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (354.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5455 mL | 17.7274 mL | 35.4547 mL | 88.6368 mL |
| 5 mM | 0.7091 mL | 3.5455 mL | 7.0909 mL | 17.7274 mL | |
| 10 mM | 0.3545 mL | 1.7727 mL | 3.5455 mL | 8.8637 mL | |
| 15 mM | 0.2364 mL | 1.1818 mL | 2.3636 mL | 5.9091 mL | |
| 20 mM | 0.1773 mL | 0.8864 mL | 1.7727 mL | 4.4318 mL | |
| 25 mM | 0.1418 mL | 0.7091 mL | 1.4182 mL | 3.5455 mL | |
| 30 mM | 0.1182 mL | 0.5909 mL | 1.1818 mL | 2.9546 mL | |
| 40 mM | 0.0886 mL | 0.4432 mL | 0.8864 mL | 2.2159 mL | |
| 50 mM | 0.0709 mL | 0.3545 mL | 0.7091 mL | 1.7727 mL | |
| 60 mM | 0.0591 mL | 0.2955 mL | 0.5909 mL | 1.4773 mL | |
| 80 mM | 0.0443 mL | 0.2216 mL | 0.4432 mL | 1.1080 mL | |
| 100 mM | 0.0355 mL | 0.1773 mL | 0.3545 mL | 0.8864 mL |
ARUK3001185 関連分類
HY-147519 関連分類
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