1365060-22-5
1365060-22-5
Chemical Structure
LP-922056
- CAS No.: 1365060-22-5
- Formula:C11H9ClN2O2S2
- Molecular Weight:300.78
IUPAC Name: 2-((6-chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio)acetic acid
InChIKey: LJYRIWUQISYYHA-UHFFFAOYSA-N
SMILES: O=C(O)CSC1=C2C(C(C3CC3)=C(Cl)S2)=NC=N1
Biological Activity: LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LP-922056 | 99.63% | LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats. | ||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.50
HY-155987CK2-IN-8 -
Similarity Score 0.48
HY-49073p38 MAP Kinase Inhibitor Ⅵ -
Similarity Score 0.48
HY-156350SGC-STK17B-1 -
Similarity Score 0.47
HY-169685p38 MAPK-IN-6 -
Similarity Score 0.47
HY-15479TTP 22 -
Similarity Score 0.46
HY-16995Pirinixic acid -
Similarity Score 0.46
HY-125972zr17-2 -
Similarity Score 0.45
HY-143254Enpp-1-IN-10 -
Similarity Score 0.44
HY-187379SARS-CoV-2 nsp3-IN-3 -
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References
- [1]. James E Tarver Jr, et al. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1525-1528. [Content Brief]
- [2]. Robert Brommage, et al. NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 2019 Jan 8;7:2. [Content Brief]
