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Cat. No.: HY-187379

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SARS-CoV-2 nsp3-IN-3

SARS-CoV-2 nsp3-IN-3 is a SARS-CoV-2 Nsp3 macrodomain (Mac1) inhibitor with an IC₅₀ value of 7.24 μM that is inactive against Mac1 hydrolytic activity at concentrations up to 1 mM. SARS-CoV-2 nsp3-IN-3 can be used for the research of covid-19.

For research use only. We do not sell to patients.

CAS No.: 3118016-51-3
Formula: C₁₃H₁₂N₂O₂S
Molecular Weight:260.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SARS-CoV-2 nsp3-IN-3 Chemical Structure

CAS No.: 3118016-51-3

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

SARS-CoV-2 nsp3-IN-3 (compound 26a) at concentrations of 200-2000 μM potently inhibits the recombinant SARS-CoV-2 Nsp3 macrodomain Mac1 in an HTRF-based in vitro peptide displacement assay, with an IC₅₀ of 7.24 μM and a ligand efficiency of 0.40^[1].
SARS-CoV-2 nsp3-IN-3 (100 mM; 1 h) binds to the active site of the recombinant SARS-CoV-2 Nsp3 macrodomain Mac1, forming specific hydrogen bonds with the Asp22, Phe156 and Asp157 residues, and this finding is confirmed by X-ray crystallography^[1].
SARS-CoV-2 nsp3-IN-3 does not inhibit the hydrolytic activity of recombinant SARS-CoV-2 Nsp3 macrodomain Mac1 even at a concentration as high as 1 mM in the AMP-Glo assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3118016-51-3
Molecular Weight 260.31
Formula C₁₃H₁₂N₂O₂S
SMILES

NC1=NC2=C(S1)C=C(C3=C(C(O)=O)CCC3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang X, et al. X-ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV-2 Nsp3 Macrodomain (Mac1). Journal of medicinal chemistry. 2026 Jul 23;69(14):16570-16600.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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