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製品番号: HY-184272

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SphK2-IN-5

SphK2-IN-5 is a selective SphK2 inhibitor with an IC₅₀ of 0.55 μM. SphK2-IN-5 exhibits anticancer activity against colon cancer and liver cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₀H₁₅N₃O₅S
分子量:409.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SphK2-IN-5 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

SphK2-IN-5 is a selective SphK2 inhibitor with an IC₅₀ of 0.55 μM. SphK2-IN-5 exhibits anticancer activity against colon cancer and liver cancer^[1].

IC₅₀ & Target^[1]

SphK2

0.55 μM (IC₅₀)

SphK アイソフォーム固有の製品をすべて表示 :

SphK1
SphK2

体外実験

SphK2-IN-5 (Compound 6a) potently and selectively inhibits SphK2 with an IC₅₀ of 0.55 μM; it shows negligible activity against SphK1 at a concentration of 10 μM^[1].
SphK2-IN-5 (48 h) exhibits potent and selective antiproliferative activity against the HCT-116, MC38, Hepa1-6 and HepG2 tumor cell lines, and shows no activity against non-tumorigenic NIH-3T3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF-7, HCT-116, MC38, Hepa1-6, HepG2, NIH-3T3
Concentration:

Different concentrations
Incubation Time:

48 h
Result:

Showed IC₅₀s of >100 μM, 10.43 μM, 1.45 μM, 9.57 μM, 0.23 μM, >100 μM for MCF-7, HCT-116, MC38, Hepa1-6, HepG2, NIH-3T3, respectively.

化学情報

分子量 409.42
分子式 C₂₀H₁₅N₃O₅S
SMILES

O=C(NC/1=O)SC1=C\C2=CN(CCOC3=CC=C([N+]([O-])=O)C=C3)C4=C2C=CC=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhang M, et al. Discovery of 1,3-disubstituted indole derivatives as ATP-competitive inhibitors of sphingosine kinase for tumor therapy. European journal of medicinal chemistry. 2026 May 22;316:118983. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
数量:
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SphK2-IN-5

SphK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

SphK2-IN-5 関連分類

HY-184272 関連分類