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Tariquidar dimesylate

(別名: XR9576 dimesylate)
57 Cited Publications
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Based on 57 publication(s) in Google Scholar

Tariquidar dimesylate (XR9576 dimesylate) is a P-glycoprotein (P-gp) inhibitor. Tariquidar dimesylate increases the concentration of the drug in the brain by binding to P-glycoprotein, preventing it from transporting the drug from inside to outside the brain. Tariquidar dimesylate can be used in the study of blood-brain barrier penetration and multidrug resistance.

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  • CAS 番号: 625375-84-0
  • 分子式: C40H46N4O12S2
  • 分子量:838.94
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Tariquidar dimesylate Chemical Structure
    Tariquidar dimesylate 構造式
  • Experimental Validation Results for Tariquidar dimesylate
  • Experimental Validation Results for Tariquidar dimesylate
  • Experimental Validation Results for Tariquidar dimesylate
  • Experimental Validation Results for Tariquidar dimesylate
  • Experimental Validation Results for Tariquidar dimesylate
CAS 番号: 625375-84-0
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  • Tariquidar dimesylate Chemical Structure
    Tariquidar dimesylate Chemical Structure
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    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Cell. 2023 Dec 7;186(25):5500-5516.e21. [Abstract]

    Customer Validation
     Survival curves of mice under SD (SR means 48 h of recovery after SD) with i.p. administration of tariquidar (n = 5) or vehicle (n = 5).

  • 1/16

    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2021 Aug 5;7(1):204. [Abstract]

    Customer Validation
     MCF-7ADR cells were treated with ADR (2μM) alone or together with Tariquidar (TQ; 0.5 μM) for 48h. Cell viability was detected using the CCK8 assays.

  • 1/16

    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2021 Jun 11;10(6):949. [Abstract]

    Customer Validation
     Tariquidar (1.5 μM; 72 h). Western blotting results show the specific inhibition of both MRP1/ABCC1 and MDR1/ABCB1 after tariquidar treatment for 72 h in both control and DEHP-exposed MDA-MB-231 clones.

  • 1/16

    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2021 Jun 11;10(6):949. [Abstract]

    Customer Validation
     Tariquidar (1.5 μM; 2 h). Enhanced Dox accumulation was observed following 2 h of Tariquidar pretreatment in DEHP-exposed MDA-MB-231 clones #1 and #2, analyzed by a BD Accuri TW C6 flow cytometer.

  • 1/16

    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Small. 2020 Nov;16(44):e2004172. [Abstract]

    Customer Validation
     In vitro tumor penetration of the DOX-loaded liposomes in BxPC3 MTS. The BxPC3 MTS were prestained with or without a Pg-p inhibitor Tariquidar (10 nM) for 3 h. Subsequently, the MTS were cultured with DOX-loaded liposomes for 6 h. The MTS were visualized using CLSM in Z-stacks with 25 µm intervals. DOX (red).

  • Tariquidar dimesylate