Trichlorfon ethyl
Trichlorfon ethyl is an analog of Trichlorfon (HY-B1220), as well as an inhibitor of Butyrylcholinesterase and Bacillus subtilis Esterase. Trichlorfon ethyl acts as a prenatal brain growth inhibitor, causing mild reductions in total brain weight, medulla oblongata weight and tectum weight in newborn guinea pigs, without affecting cerebellar weight. Trichlorfon ethyl does not induce severe prenatal brain hypoplasia in guinea pig offspring. Trichlorfon ethyl can be used in studies related to brain hypoplasia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 993-86-2
- 分子式: C6H12Cl3O4P
- 分子量:285.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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BChE |
Trichlorfon ethyl (Compound Ih) (0.1 mM; 1-10 min) inhibits butyrylcholinesterase from horse blood serum with a kII of 2.75×103 L mol-1 min-1 and Bacillus subtilis esterase with a kII of 4.06×102 L mol-1 min-1[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Outbred albino guinea pigs (Ssc:AL, Mol:DHF; pregnant dams)[1]
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Dosage:125 mg/kg (gestational days 44, 45, 46); 138 mg/kg (gestational day 42); 121 mg/kg (gestational day 44)
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Administration:Single dose on specified gestational days
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Result:Showed no significant reductions in total brain weight or weights of cerebellum, medulla oblongata, diencephalon, hippocampus, quadrigemina, or cerebral cortex in offspring exposed to 125 mg/kg, compared to saline controls.
Showed a significant reduction in total brain weight (mean 2.47 g, p < 0.05), medulla oblongata weight (mean 163 mg, p < 0.05), and quadrigemina weight (mean 73 mg, p < 0.05), but no significant reduction in cerebellum weight in offspring exposed to 138 mg/kg (day 42) and 121 mg/kg (day 44).
Reduced red blood cell acetylcholinesterase activity to 51% of control levels 24 hours after administration of 125 mg/kg.
Observed no significant changes in glutamate decarboxylase, choline acetyltransferase, or acetylcholinesterase activities in cerebellum, medulla, or cerebral cortex of offspring exposed to ethyl-trichlorfon.
化学情報
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CAS 番号 993-86-2
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分子量 285.49
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分子式 C6H12Cl3O4P
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SMILES
ClC(Cl)(C(O)P(OCC)(OCC)=O)Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Trichlorfon ethyl 関連分類
HY-113737 関連分類
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