2. GPCR/G Protein Neuronal Signaling
  3. Amylin Receptor CGRP Receptor
  4. KBP-089

KBP-089 is a dual Amylin and Calcitonin Receptor agonist. KBP-089 reduces body weight, decreases adipose tissue mass and improves glucose tolerance in obese rats. KBP-089 also eliminates lipid accumulation in the liver and muscle, and ameliorates glycemic homeostasis and insulin sensitivity. KBP-089 is applicable to the research of diseases such as obesity and type 2 diabetes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

KBP-089

KBP-089 Chemical Structure

CAS No. : 1776112-67-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

KBP-089 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KBP-089 is a dual Amylin and Calcitonin Receptor agonist. KBP-089 reduces body weight, decreases adipose tissue mass and improves glucose tolerance in obese rats. KBP-089 also eliminates lipid accumulation in the liver and muscle, and ameliorates glycemic homeostasis and insulin sensitivity. KBP-089 is applicable to the research of diseases such as obesity and type 2 diabetes[1][2].

In Vitro

KBP-089 (3 h) potently activates human CTR and AMY3-R in heterologous cell lines with its pEC50 values ranging from 8.7 to 9.9, and can induce sustained receptor activation for up to 72 hours[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KBP-089 Related Antibodies
In Vivo

KBP-089 (5 μg/kg; s.c.; once daily/once every other day; 15 days) produces comparable body weight reduction effects in high-fat diet-fed rats[1].
KBP-089 (0.625-40 μg/kg; s.c.; 6 weeks) reduces body weight and improves glucose tolerance in high-fat diet-fed rats following 4-fold dose escalation administration[1].
KBP-089 (0.625-40 μg/kg; s.c.; single dose) dose-dependently suppresses caloric intake in overnight-fasted high-fat diet-fed rats within 48 h[1].
KBP-089 (5-20 μg/kg; s.c.; 8 weeks total) reduces blood glucose levels, improves glucose tolerance and enhances insulin action in diabetic obese rats[2].
KBP-089 (2.5 µg/kg; s.c.; 7 days) reduces total caloric intake in rats fed a normal diet and shifts their food preference from chocolate to standard chow[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male, 18 weeks of age, high-fat diet-induced obesity model)[1]
Dosage: 0.625, 2.5, 10, 40 μg/kg
Administration: s.c.; 4-fold dose escalation followed by 6 weeks of maintenance at final dose
Result: Induced transient food intake reduction at each dose escalation step (magnitude decreasing over time).
Caused ~15% vehicle-corrected weight loss, corresponding adipose tissue reduction, and improved oral glucose tolerance at 2.5, 10, or 40 μg/kg.
Animal Model: Zucker Diabetic Fatty (ZDF-Leprfa/Crl) rats (male, 6 weeks old)[2]
Dosage: 5 µg/kg (first 4 weeks) and 20 µg/kg (additional 4 weeks)
Administration: s.c.; daily; 8 weeks total
Result: Reduced fasting blood glucose over 7 weeks.
Reduced HbA1c at study end; Lowered oral glucose tolerance test tAUC.
Increased insulin sensitivity.
Molecular Weight

3529.98

Formula

C148H242N46O48S3
CAS No.
Sequence

Ac-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Arg-Leu-Ser-Gln-Asp-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Lys-Thr-Asp-Val-Gly-Ala-Asn-Ala-Pro-NH2 (Disulfide bridge: Cys1-Cys7)
Sequence Shortening

Ac-CSNLSTCMLGRLSQDLHRLQTYPKTDVGANAP-NH2 (Disulfide bridge: Cys1-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

KBP-089 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KBP-0891776112-67-4KBP089KBP 089Amylin ReceptorCGRP ReceptorAMYRCalcitonin gene-related peptide receptorcalcitonin receptorratstype 2 diabetesliver tissueinsulinglucose homeostasisobesityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
KBP-089
Cat. No.:
HY-P11610
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.