1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. KCC-07

KCC-07 

Cat. No.: HY-131031
Handling Instructions

KCC-07 is a potent, selective and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity.

For research use only. We do not sell to patients.

KCC-07 Chemical Structure

KCC-07 Chemical Structure

CAS No. : 315702-75-1

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Description

KCC-07 is a potent, selective and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity[1].

IC50 & Target

MBD2 (methyl-CpG-binding domain protein 2)[1]

In Vitro

KCC-07 (10 μM; 72 hours; MB cells) treatment clearly inhibited MB cell growth in vitro, consistent with induction of anti-proliferative BAI1/p53/p21 signaling[1].
KCC-07 (10 μM; 48 hours; MB cells) treatment largely abrogates MBD2 binding to the ADGRB1 promoter and restores BAI1 mRNA and protein expression in BAI1-silent MB cells[1].

Cell Viability Assay[1]

Cell Line: Medulloblastomas (MB) cells
Concentration: 10 μM
Incubation Time: 72 hours
Result: Clearly inhibited MB cell growth in vitro.

Western Blot Analysis[1]

Cell Line: Medulloblastomas (MB) cells
Concentration: 10 μM
Incubation Time: 48 hours
Result: Largely abrogated MBD2 binding to the ADGRB1 promoter in BAI1-silent MB cells.
In Vivo

KCC-07 (100 mg/kg; intraperitoneal injection; 5 days/week; athymic nude mice) treatment inhibits tumor growth and significantly extends the survival of MB xenografts in vivo[1].

Animal Model: Outbred athymic nude mice (females; 8-10 weeks old) injected with MB cells[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection; 5 days/week
Result: Significantly extended the survival of MB xenografts in vivo.
Molecular Weight

269.32

Formula

C₁₄H₁₁N₃OS

CAS No.

315702-75-1

SMILES

OC1=CC=CC(NC2=NC(C3=NC=CC=C3)=CS2)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

KCC-07KCC07KCC 07DNA Alkylator/CrosslinkerADGRBAI1MBD2brain-penetrantanticancerADGRB1anti-proliferativep53Inhibitorinhibitorinhibit

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KCC-07
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HY-131031
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