315702-75-1
Chemical Structure
KCC-07
- CAS No.: 315702-75-1
- Formula:C14H11N3OS
- Molecular Weight:269.32
IUPAC Name: 3-((4-(pyridin-2-yl)thiazol-2-yl)amino)phenol
InChIKey: GIGNWEDIMLUWCT-UHFFFAOYSA-N
SMILES: OC1=CC=CC(NC2=NC(C3=NC=CC=C3)=CS2)=C1
Biological Activity: KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling[1]. KCC-07 is a TRACER (transcriptional regulation via active control of epigenetic reprogramming) that can stimulate ER transcriptional activity[2]. KCC-07 can be used for the stduy of breast cancer[1].
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KCC-07 | 99.95% | KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. KCC-07 is a TRACER (transcriptional regulation via active control of epigenetic reprogramming) that can stimulate ER transcriptional activity. KCC-07 can be used for the stduy of breast cancer. | ||||||||||||||||||||
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- [1]. Dan Zhu, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5. [Content Brief]
- [2]. Stieger CE, et al. Targeted Transcriptional Repression by Induced Proximity. bioRxiv [Preprint]. 2025 Oct 22:2025.10.22.680877. [Content Brief]
Keywords
