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  3. ICA

ICA  (Synonyms: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)

Cat. No.: HY-22044 Purity: 99.63%
COA Handling Instructions

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

For research use only. We do not sell to patients.

ICA Chemical Structure

ICA Chemical Structure

CAS No. : 3374-88-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 504 In-stock
Solution
10 mM * 1 mL in DMSO USD 504 In-stock
Solid
1 mg USD 180 In-stock
5 mg USD 360 In-stock
10 mg USD 540 In-stock
50 mg USD 1200 In-stock
100 mg USD 1680 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

IC50 & Target

IC50: 2.1 µM (Antileishmanial)[1]

In Vitro

The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

254.31

Formula

C13H10N4S

CAS No.
Unlabeled CAS

Appearance

Solid

Color

Light brown to brown

SMILES

C1(NC2=NC(C3=NC=CC=C3)=CS2)=NC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 49.5 mg/mL (194.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9322 mL 19.6610 mL 39.3221 mL
5 mM 0.7864 mL 3.9322 mL 7.8644 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9322 mL 19.6610 mL 39.3221 mL 98.3052 mL
5 mM 0.7864 mL 3.9322 mL 7.8644 mL 19.6610 mL
10 mM 0.3932 mL 1.9661 mL 3.9322 mL 9.8305 mL
15 mM 0.2621 mL 1.3107 mL 2.6215 mL 6.5537 mL
20 mM 0.1966 mL 0.9831 mL 1.9661 mL 4.9153 mL
25 mM 0.1573 mL 0.7864 mL 1.5729 mL 3.9322 mL
30 mM 0.1311 mL 0.6554 mL 1.3107 mL 3.2768 mL
40 mM 0.0983 mL 0.4915 mL 0.9831 mL 2.4576 mL
50 mM 0.0786 mL 0.3932 mL 0.7864 mL 1.9661 mL
60 mM 0.0655 mL 0.3277 mL 0.6554 mL 1.6384 mL
80 mM 0.0492 mL 0.2458 mL 0.4915 mL 1.2288 mL
100 mM 0.0393 mL 0.1966 mL 0.3932 mL 0.9831 mL
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ICA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ICA
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