1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. KLH45

KLH45 

Cat. No.: HY-103060 Purity: >98.0%
Handling Instructions

KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM.

For research use only. We do not sell to patients.

KLH45 Chemical Structure

KLH45 Chemical Structure

CAS No. : 1632236-44-2

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5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 330 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM[1].

In Vitro

KLH45 (25 nM, 4 h) completely inactivats DDHD2 (>95% inhibition) in Neuro2A cells and shows no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6[1].
KLH45 (2 μM) increases LD formation in fatty acid-supplemented DDHD2-expressing cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: COS-7 cells.
Concentration: 2 μM.
Incubation Time: 16 h.
Result: Selectively blocked DDHD2 activity.
In Vivo

KLH45 (20 mg/kg; administered every 12 h) for a total of 4 d exhibits significant elevations in several of the TAGs that accumulated in the brains of DDHD2−/− mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1].
Dosage: 5-40 mg/kg.
Administration: IP, once.
Result: Did not show altered brain TAGs.
Molecular Weight

458.48

Formula

C₂₄H₂₅F₃N₄O₂

CAS No.

1632236-44-2

SMILES

O=C(N1N=CC(C2=CC=C(OC(F)(F)F)C=C2)=N1)N(C3CCCCC3)CCC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >98.0%

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Keywords:

KLH45KLH 45KLH-45PhosphataseInhibitorinhibitorinhibit

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KLH45
Cat. No.:
HY-103060
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