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Cat. No.: HY-12767

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Carvedilol metabolite 4-Hydroxyphenyl Carvedilol

(Synonyms: 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol)

4-Hydroxyphenyl Carvedilol, a metabolite of Carvedilol, is an active metabolite of Carvedilol (HY-B0006) and is produced via CYP2D6-mediated oxidation.

For research use only. We do not sell to patients.

Purity: 98.42%
CAS No.: 142227-49-4
Formula: C₂₄H₂₆N₂O₅
Molecular Weight:422.47

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol Chemical Structure

CAS No.: 142227-49-4

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

4-Hydroxyphenyl Carvedilol, a metabolite of Carvedilol, is an active metabolite of Carvedilol (HY-B0006) and is produced via CYP2D6-mediated oxidation^[1].

IC₅₀ & Target^[1]

CYP2D6

All Cytochrome P450 Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	10.4 μM Compound: 3	Inhibition of RyR2 R4496C mutant-mediated store overload-induced calcium release in HEK293 cells assessed as reduction in amplitude of spontaneous calcium oscillations by fura-2 AM dye based fluorescence assay Inhibition of RyR2 R4496C mutant-mediated store overload-induced calcium release in HEK293 cells assessed as reduction in amplitude of spontaneous calcium oscillations by fura-2 AM dye based fluorescence assay	[PMID: 26584883]

In Vitro

4-Hydroxyphenyl Carvedilol, a metabolite of Carvedilol, is an active metabolite of Carvedilol (HY-B0006) and is formed via CYP2D6-mediated oxidation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 142227-49-4
Appearance Solid
Molecular Weight 422.47
Formula C₂₄H₂₆N₂O₅
Color White to off-white
SMILES

OC1=CC=C(OCCNCC(O)COC2=CC=CC(N3)=C2C4=C3C=CC=C4)C(OC)=C1
Synonyms

4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang Y, et al. Simultaneous quantification of vortioxetine, carvedilol and its active metabolite 4-hydroxyphenyl carvedilol in rat plasma by UPLC-MS/MS: Application to their pharmacokinetic interaction study. J Pharm Biomed Anal. 2016;128:184-190. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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Carvedilol metabolite 4-Hydroxyphenyl Carvedilol

Metabolism/Protease Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

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All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol

Metabolism/Protease Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Mitochondria-Targeted Compound Library

Drug Metabolite Library

Human Metabolite Library

Metabolic Enzyme Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol Related Classifications

Cat. No.: HY-12767