Calcitroic acid-13C
Calcitroic acid-13C is the 13C-labeled Calcitroic acid (HY-N10508). Calcitroic acid is a water-soluble terminal vitamin D metabolite and also a ligand for vitamin D receptor (VDR). Calcitroic acid binds to the ligand-binding domain of VDR, forms a retinoic X receptor complex, recruits the coactivator peptide MED1, mediates partial VDR-dependent transcription, inhibits Calcitriol (HY-10002)-induced VDR activation, and reduces the transcription level of CYP24A1 in the presence of 1α,25-dihydroxyvitamin D3. Calcitroic acid exerts selective activating effects on VDR, upregulates the expression of CYP24A1 and CYP3A4, decreases the transcription levels of iNOS and IL-1β, reduces the secretion of nitric oxide and IL-1β, and possesses metabolic stability due to its resistance to phase I oxidation and hepatic glucuronidation. Calcitroic acid can be used in research related to colon cancer, inflammatory bowel disease and rickets.
For research use only. We do not sell to patients.
- CAS No.: 1637678-42-2
- Formula: C2213CH34O4
- Molecular Weight:375.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1637678-42-2
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Unlabeled Cas 71204-89-2
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Molecular Weight 375.51
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Formula C2213CH34O4
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)C[13C](O)=O)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Teske KA, et al. Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. European journal of medicinal chemistry. 2016 Feb 15;109:238-46. [Content Brief]
[2]. Yu OB, et al. Biological evaluation and synthesis of calcitroic acid. Bioorg Chem. 2021 Nov;116:105310. [Content Brief]
[5]. Yu OB, et al. Synthesis and biological evaluation of calcioic acid. Steroids. 2020 Feb;154:108536. [Content Brief]
[6]. Zimmerman DR, et al. Calcitroic acid is a major catabolic metabolite in the metabolism of 1 alpha-dihydroxyvitamin D(2). Arch Biochem Biophys. 2001 Aug 1;392(1):14-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Calcitroic acid-13C Related Classifications
HY-N10508S Related Classifications
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